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Invitrogen
LONP1 Polyclonal Antibody
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LONP1 Antibody (PA5-49215) in WB
Western blot analysis of LONP1 in various lysates. Samples were incubated with LONP1 polyclonal antibody (Product # PA5-49215) using a dilution of 1:2,000 followed by Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at a dilution of 1:10,000. Lysates/proteins: 20 µg per lane. Lane 1: Hela whole cell lysate; Lane 2: 293 whole cell lysate. Predicted band size: 106 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-49215
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 389-418 amino acids from the Central region of human LONP1.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.35
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Predicted to react with bovine, mouse and rat based on sequence homology.
靶标信息
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia. Alternatively spliced transcript variants have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: h LonHS; Lon protease homolog, mitochondrial; Lon protease-like protein; LONHs; LONP; Mitochondrial ATP-dependent protease Lon; protease, serine, 15; Serine protease 15
基因别名: 1200017E13Rik; LON; LONP1; PRSS15
UniProt ID: (Mouse) Q8CGK3
Entrez Gene ID: (Mouse) 74142
nucleotide binding
DNA binding
single-stranded DNA binding
single-stranded RNA binding
ATP-dependent peptidase activity
serine-type endopeptidase activity
ATP binding
peptidase activity
serine-type peptidase activity
hydrolase activity
ATPase activity
ADP binding
sequence-specific DNA binding
G-quadruplex DNA binding
DNA polymerase binding
mitochondrial light strand promoter anti-sense binding
mitochondrial heavy strand promoter anti-sense binding
mitochondrial light strand promoter sense binding
mitochondrial heavy strand promoter sense binding
serine protease
proteolysis
misfolded or incompletely synthesized protein catabolic process
mitochondrion organization
protein catabolic process
cellular response to oxidative stress
cellular protein complex assembly
chaperone-mediated protein complex assembly
protein homooligomerization
proteolysis involved in cellular protein catabolic process
oxidation-dependent protein catabolic process
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
