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Invitrogen
Urokinase Polyclonal Antibody
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FIGURE: 1 / 2
Urokinase Antibody (PA5-49297) in WB
Western blot analysis of Urokinase in Mouse lung lysate. Samples were incubated with Urokinase polyclonal antibody (Product # PA5-49297) using a dilution of 1:1,000 followed by Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at a dilution of 1:10,000. Lysates/proteins: 20 µg per lane. Predicted band size: 48 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-49297
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 304-331 amino acids from the C-terminal region of mouse Plau.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antagonist of uPA; CD87; HGNC:9052; plasminogen activator; plasminogen activator, urinary; preprourokinase; pro-urokinase; u-PA; U-plasminogen activator; unnamed protein product; uPA; uPA ATF; antagonist of uPA; UPAR; URKR
Gene Aliases: ATF; BDPLT5; QPD; u-PA; UPA; URK
UniProt ID: (Human) P00749, (Mouse) P06869
Entrez Gene ID: (Human) 5328, (Mouse) 18792
angiogenesis
response to hypoxia
proteolysis
epidermal growth factor receptor signaling pathway
positive regulation of cell proliferation
regulation of plasminogen activation
negative regulation of plasminogen activation
smooth muscle cell migration
regulation of smooth muscle cell migration
positive regulation of smooth muscle cell migration
regulation of cell adhesion
positive regulation of cell migration
plasminogen activation
regulation of cell adhesion mediated by integrin
urokinase plasminogen activator signaling pathway
regulation of cell proliferation
fibrinolysis
skeletal muscle tissue regeneration
positive regulation of epidermal growth factor receptor signaling pathway
regulation of fibrinolysis
negative regulation of fibrinolysis
regulation of wound healing
positive regulation of extracellular matrix disassembly
regulation of smooth muscle cell-matrix adhesion
regulation of hepatocyte proliferation
positive regulation of reactive oxygen species metabolic process
regulation of integrin-mediated signaling pathway
chemotaxis
signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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