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Invitrogen
KIR2DL5A/KIR2DL5B Polyclonal Antibody
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Product Details
PA5-68460
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human KIR2DL5A/KIR2DL5B [aa 121-170].
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with Human samples.
Target Information
KIR2DL5A and KIR2DL5B are Killer cell immunoglobulin-like receptors (KIRs), transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. KIR proteins are thought to play an important role in regulation of the immune response. Functionally, KIR2DL5A and KIR2DL5B are receptors on natural killer (NK) cells for HLA-C alleles and prevent cell lysis by inhibiting the activity of NK cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD158 antigen-like family member F2; CD158f1; CD158f2; killer cell immunoglobulin-like receptor 2DL5; Killer cell immunoglobulin-like receptor 2DL5A; Killer cell immunoglobulin-like receptor 2DL5B; Killer cell immunoglobulin-like receptor 2DLX; killer cell immunoglobulin-like receptor KIR2DL5A; killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 5; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5B; killer Ig receptor; killer-cell Ig-like receptor
Gene Aliases: CD158F; CD158F1; CD158F2; KIR2DL5; KIR2DL5.1; KIR2DL5.2; KIR2DL5.3; KIR2DL5A; KIR2DL5B; KIR2DLX
UniProt ID: (Human) Q8N109, (Human) Q8NHK3
Entrez Gene ID: (Human) 57292, (Human) 553128
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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