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Invitrogen
GRIK1 Polyclonal Antibody
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Product Details
PA5-68669
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the middle region of mouse GRK1
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
Target Information
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik1, also known as glutamate receptor 5, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik1 is expressed in GABAergic interneurons of the hippocampus and are thought to participate in the formation of various subtypes of kainate receptors with Grik2 and KA2. Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological and neurodegenerative diseases. Numerous isoforms of Grik1 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: glutamate receptor; glutamate receptor subunit 5; unnamed protein product
Gene Aliases: A830007B11Rik; D16Ium24; D16Ium24e; GluK1; GluK5; Glur-5; Glur5; Glurbeta1
Entrez Gene ID: (Mouse) 14805
SNARE binding
ionotropic glutamate receptor activity
ion channel activity
extracellular-glutamate-gated ion channel activity
L-glutamate transmembrane transporter activity
protein binding
ligand-gated ion channel activity
kainate selective glutamate receptor activity
glutamate binding
glutamate-gated calcium ion channel activity
signaling receptor activity
identical protein binding
scaffold protein binding
ligand-gated monoatomic cation channel activity
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
heterocyclic compound binding
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
ion transport
nervous system development
positive regulation of gamma-aminobutyric acid secretion
L-glutamate transport
calcium-mediated signaling
adult behavior
negative regulation of synaptic transmission, GABAergic
positive regulation of synaptic transmission, GABAergic
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
regulation of membrane potential
regulation of long-term neuronal synaptic plasticity
regulation of short-term neuronal synaptic plasticity
behavioral response to pain
modulation of synaptic transmission
membrane depolarization
negative regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
inhibitory postsynaptic potential
cation transmembrane transport
modulation of excitatory postsynaptic potential
regulation of presynaptic membrane potential
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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