Search
Invitrogen
KCNQ2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
{{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation']}}:
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-68676
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the middle region of human KCNQ2 (aa 182-231)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 93%
Target Information
KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system and KNCQ2 and 3 have demonstrated their importance in M-current activation. Studies have shown that KCNQ2 and KCNQ3 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: KQT like 2; KQT-like 2; KVEBN1; potassium channel subunit alpha KvLQT2; unnamed protein product; voltage-gated potassium channel subunit Kv7.2
Gene Aliases: HNSPC; KQT2; Nmf134
UniProt ID: (Mouse) Q9Z351
Entrez Gene ID: (Mouse) 16536
action potential
protein phosphorylation
protein import into nucleus
ion transport
potassium ion transport
exocytosis
endocytosis
brain development
sensory perception of sound
learning
memory
grooming behavior
determination of adult lifespan
response to temperature stimulus
response to xenobiotic stimulus
response to mechanical stimulus
gene expression
response to auditory stimulus
protein transport
neuron remodeling
transmission of nerve impulse
neuronal action potential
dentate gyrus development
nerve development
hippocampus development
establishment of cell polarity
neuron differentiation
ion transmembrane transport
social behavior
exploration behavior
sodium ion transmembrane transport
psychomotor behavior
regulation of membrane potential
regulation of synaptic plasticity
cognition
neuron apoptotic process
mitochondrial depolarization
transmembrane transport
motor behavior
cellular response to calcium ion
cellular response to xenobiotic stimulus
potassium ion transmembrane transport
apoptosome assembly
hippocampal pyramidal neuron differentiation
excitatory chemical synaptic transmission
inhibitory chemical synaptic transmission
action potential initiation
regulation of action potential firing threshold
substantia propria of cornea development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support