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Invitrogen
FZD10 Polyclonal Antibody
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图: 1 / 4
FZD10 Antibody (PA5-75325) in IHC (P)
Immunohistochemistry analysis of FZD10 in paraffin-embedded human breast carcinoma tissue (cell membrane staining) and negative control (right, with PBS only). Samples were incubated with FZD10 polyclonal antibody (Product # PA5-75325) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-75325
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 132-180 of Human FZD10.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
FZD10/Frizzled-10 is a 581 amino acid protein belonging to the G-protein coupled receptor Fz/Smo family and containing a signal peptide, a cysteine-rich domain in the N-terminal, seven transmembrane domains and a C-terminal PDZ domain-binding motif. It is involved in transduction, intercellular transmission of polarity information during tissue morphogenesis in differentiated tissues and as a receptor for Wnt proteins. FZD10 is expressed highly in placenta, fetal kidney, fetal lung, brain cerebellum, cerebral cortex, medulla and spinal cord with very low levels in total brain, frontal lobe, temporal lobe, putamen, adult brain, heart, lung and skeletal muscle.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD350; CD350 antigen; frizzled family receptor 10; frizzled homolog 10, pseudogene 1; Frizzled-10; Fz-10; FzE7
基因别名: Fz-10; Fz10; FZD10; Fzd10-ps1
UniProt ID: (Mouse) Q8BKG4
Entrez Gene ID: (Rat) 363913, (Mouse) 93897
biological_process
Wnt signaling pathway
regulation of actin cytoskeleton organization
non-canonical Wnt signaling pathway via JNK cascade
positive regulation of JUN kinase activity
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
multicellular organism development
negative regulation of GTPase activity
non-canonical Wnt signaling pathway
positive regulation of GTPase activity
canonical Wnt signaling pathway
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
