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Invitrogen
Aquaporin 2 Polyclonal Antibody
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Product Details
PA5-78808
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Aquaporin 2 (245-260aa DWEEREVRRRQSVELH).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: MCF-7 Cell, SW620 Cell, HT1080 Cell. IHC: Rat Kidney Tissue IHC-F: Rat Kidney Tissue.
Target Information
Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans. A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells. Recently, serine-261 has been identified as a novel phosphorylation site on AQP2 and levels of phosphorylated S261 have been shown to decrease with vasopressin treatment suggesting its involvement in vasopressin-dependent AQP2 trafficking.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ADH water channel; AQP 2; AQP CD; AQP-2; AQP-CD; AQP2; AQPCD; aquaporin 2 (collecting duct); Aquaporin CD; Aquaporin-2; Aquaporin-CD; Aquaporin2; Aquaporine 2; Collecting duct water channel protein; MGC34501; Water channel protein for renal collecting duct; water-channel aquaporin 2; WCH CD; WCH-CD; WCHCD
Gene Aliases: AQP-2; AQP-CD; AQP2; aquaporin-2; cph; jpk; NDI2; WCH-CD
UniProt ID: (Human) P41181, (Mouse) P56402, (Rat) P34080
Entrez Gene ID: (Human) 359, (Mouse) 11827, (Rat) 25386
renal water homeostasis
renal water transport
water transport
actin filament organization
glycerol transport
cellular response to water deprivation
protein homotetramerization
transmembrane transport
cellular response to copper ion
cellular response to mercury ion
metanephric collecting duct development
transport
cell volume homeostasis
apoptotic process
cellular water homeostasis
actin filament depolymerization
carbohydrate transmembrane transport
ion transmembrane transport
positive regulation of calcium ion transport
hyperosmotic response
female pregnancy
aging
response to water deprivation
response to salt stress
response to hormone
response to lithium ion
water homeostasis
response to lipopolysaccharide
response to glucagon
response to starvation
response to calcium ion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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