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Invitrogen
14-3-3 zeta Polyclonal Antibody
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图: 1 / 7
14-3-3 zeta Antibody (PA5-80245) in ICC/IF
Immunofluorescence analysis of YWHAZ was performed using 70% confluent log phase PC-3 cells. The cells were fixed with 4% Paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 10 minutes at room temperature. The cells were labeled with PLP1 Monoclonal Antibody (plpc 1) (Product # PA5-80245) at 1:250 dilution in 0.1% BSA, incubated at 4 degree cels... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-80245
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence of human 14-3-3 zeta/delta (LLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQ).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.01mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human HepG2 whole cell, human THP-1 whole cell, human Raji whole cell, human A549 whole cell, human A431 whole cell, human PC-3 whole cell, human MCF-7 whole cell, human SiHa whole cell, rat brain tissue, rat kidney tissue, rat RH35 whole cell, rat PC-12 whole cell, mouse brain tissue, mouse kidney tissue, mouse ANA-1 whole cell, mouse Neuro-2a whole cell. ICC/IF: U2OS cell.
靶标信息
At least seven isoforms comprise the highly conserved 14-3-3 family of homo- and heterodimeric proteins that are abundantly expressed in all eukaryotic cells. Although more than seven isoforms of 14-3-3 have been described, some redundancies have appeared upon sequencing. The 14-3-3s are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. By interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle and through interaction with Bad, prevents apoptosis. Other proteins that have been shown to bind to 14-3-3s include members of the protein kinase C family, Cbl, IRS-1, polyoma middle-T antigen, nitrate reductase, S-raf and the IGF-1 receptor. Detection of 14-3-3 proteins in cerebrospinal fluid has been shown to be useful in the differential diagnosis of Creutzfeldt-Jakob disease and other prion diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 14-3-3 protein zeta/delta; 14-3-3 zeta; 1433Z; 143Z; KCIP-1; Mitochondrial import stimulation factor S1 subunit; Protein kinase C inhibitor protein 1; SEZ-2; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
基因别名: 1110013I11Rik; 14-3-3z; 14-3-3zeta; AI596267; AL022924; AU020854; Msfs1; YWHAZ
UniProt ID: (Mouse) P63101, (Rat) P63102
Entrez Gene ID: (Mouse) 22631, (Rat) 25578
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