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Invitrogen
RBM15 Polyclonal Antibody
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FIGURE: 1 / 2
RBM15 Antibody (PA5-92321) in IHC (P)
Immunohistochemistry analysis of RBM15 in paraffin-embedded human colon carcinoma. Samples were incubated with RBM15 Polyclonal antibody (Product # PA5-92321) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-92321
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 530-780 of human RBM15 (NP_0011884741)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.38 mg/mL
Amount
38 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EHRYQQQYLQ PLPLTHYELV TDAFGHRAPD PLRGARDRTP PLLYRDRDRD LYPDSDWVPP PPPVRERSTR TAATSVPAYE PLDSLDRRRD GWSLDRDRGD RDLPSSRDQP RKRRLPEESG GRHLDRSPES DRPRKRHCAP SPDRSPELSS SRDRYNSDND RSSRLLLERP SPIRDRRGSL EKSQGDKRDR KNSASAERDR KHRTTAPTEG KSPLKKEDRS DGSAPSTSTA SSKLKSPSQK QDGGTAPVAS A; Positive Samples: HL-60, HepG2, 293T, Jurkat, Mouse thymus, Mouse spleen; Cellular Location: Nucleus, Nucleus membrane, Nucleus speckle, Peripheral membrane protein, nucleoplasm
Target Information
May function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: one twenty two protein; one twenty-two; One-twenty two protein 1; putative RNA-binding protein 15; RBM15L; RBM15s; RBM15s+ae; RNA-binding motif protein 15; RNA-binding protein 15; unnamed protein product
Gene Aliases: C230088J01Rik; Kiaa4257; mKIAA1438; OTT; OTT1; RBM15; SPEN
UniProt ID: (Human) Q96T37, (Mouse) Q0VBL3
Entrez Gene ID: (Human) 64783, (Mouse) 229700
regulation of alternative mRNA splicing, via spliceosome
RNA methylation
patterning of blood vessels
positive regulation of transcription of Notch receptor target
dosage compensation by inactivation of X chromosome
thrombopoietin-mediated signaling pathway
regulation of myeloid cell differentiation
negative regulation of myeloid cell differentiation
regulation of megakaryocyte differentiation
negative regulation of transcription, DNA-templated
spleen development
ventricular septum morphogenesis
placenta blood vessel development
negative regulation of transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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