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Invitrogen
AIRE Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-95921
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.57 mg/mL
Amount
157 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: MCF7, U-937, HT-29, OVCAR3, SW620, Mouse kidney, Mouse liver; Cellular Location: Cytoplasm, Nucleus
Immunogen sequence: HALADHDVVP EDKFQETLHL KEKEGCPQAF HALLSWLLTQ DSTAILDFWR VLFKDYNLER YGRLQPILDS FPKDVDLSQP RKGRKPPAVP KALVPPPRLP T
Target Information
AIRE is a transcriptional regulator protein that binds to DNA as a dimer and tetramer, but not as a monomer, and may be involved in the regulation of gene expression. A nuclear protein, AIRE is a 545 amino acid protein with an HSR domain, two PHD type zinc fingers, and a SAND domain, and may be present in soluble high-molecular-weight complexes. It may form homodimer, homotetramer and also nuclear bodies and interacts with the transcriptional coactivator CBP and CREBBP. Three isoforms of AIRE are reported and one of them is predicted to be a candidate for nuclear-mediated decay (NMD). AIRE is involved in immune regulation and is known to mediate E3 ubiquitin ligase activity. Defects in AIRE are responsible for the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AIRE protein; alternatively spliced product 1b; alternatively spliced product 1d; alternatively spliced product 2a; alternatively spliced product 2b; alternatively spliced product 2c; alternatively spliced product 2d; alternatively spliced product 3a; alternatively spliced product 3b; alternatively spliced product 3c; APECED protein homolog; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog; autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); autoimmune regulator AIRE1a; DNA-binding protein; OTTHUMP00000109529
Gene Aliases: AIRE1; APECED; APS1; APSI; PGA1
UniProt ID: (Human) O43918, (Mouse) Q9Z0E3
Entrez Gene ID: (Human) 326, (Mouse) 11634, (Rat) 294328
peripheral T cell tolerance induction
tolerance induction
central tolerance induction to self antigen
regulation of transcription, DNA-templated
regulation of translation
immune response
humoral immune response
positive regulation of chemokine production
negative thymic T cell selection
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
thymus epithelium morphogenesis
regulation of thymocyte migration
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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