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Invitrogen
HEC1 Polyclonal Antibody
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HEC1 Antibody (PA5-96314) in WB
Western blot analysis of HEC1 in extracts of various cell lines. Samples were incubated with HEC1 Polyclonal antibody (Product # PA5-96314) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-96314
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 343-642 of human HEC1/HEC1/NDC80 (NP_0060921)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.49 mg/mL
规格
149 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: ETIKQENTRL QNIIDNQKYS VADIERINHE RNELQQTINK LTKDLEAEQQ KLWNEELKYA RGKEAIETQL AEYHKLARKL KLIPKGAENS KGYDFEIKFN PEAGANCLVK YRAQVYVPLK ELLNETEEEI NKALNKKMGL EDTLEQLNAM ITESKRSVRT LKEEVQKLDD LYQQKIKEAE EEDEKCASEL ESLEKHKHLL ESTVNQGLSE AMNELDAVQR EYQLVVQTTT EERRKVGNNL QRLLEMVATH VGSVEKHLEE QIAKVDREYE ECMSEDLSEN IKEIRDKYEK KATLIKSSEE; Positive Samples: K-562, Lovo, MCF7, 22Rv1, THP-1, 293T, Mouse testis; Cellular Location: Chromosome, Nucleus, centromere, kinetochore
靶标信息
Hec1 is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HEC-1; HEC2; HEC4; highly expressed in cancer, rich in leucine heptad repeats; kinetochore associated 2; Kinetochore protein Hec1; Kinetochore protein NDC80 homolog; Kinetochore-associated protein 2
基因别名: 2610020P18Rik; AV139730; HEC; HEC1; Kntc2; Ndc80
UniProt ID: (Mouse) Q9D0F1
Entrez Gene ID: (Mouse) 67052
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