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Invitrogen
NUMB Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-97209
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 521-640 of human NUMB (NP_0037353)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.51 mg/mL
Amount
151 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SQMVANVFGT AGHPQAAHPH QSPSLVRQQT FPHYEASSAT TSPFFKPPAQ HLNGSAAFNG VDDGRLASAD RHTEVPTGTC PVDPFEAQWA ALENKSKQRT NPSPTNPFSS DLQKTFEIEL; Positive Samples: HeLa, LO2, U-87MG, HT-1080, SW480, A-549, Rat liver; Cellular Location: Membrane, Peripheral membrane protein
Target Information
Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: m-Nb; m-numb; mnb; numb gene homolog; Protein numb homolog
Gene Aliases: Nb; Numb
UniProt ID: (Mouse) Q9QZS3
Entrez Gene ID: (Mouse) 18222, (Rat) 29419
multicellular organism development
nervous system development
neuroblast proliferation
axonogenesis
lateral ventricle development
neuroblast division in subventricular zone
positive regulation of cell migration
positive regulation of polarized epithelial cell differentiation
forebrain development
adherens junction organization
regulation of neuron differentiation
negative regulation of Notch signaling pathway
positive regulation of neurogenesis
positive regulation of dendrite morphogenesis
lung epithelial cell differentiation
negative regulation of protein localization to plasma membrane
cell proliferation
cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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