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Invitrogen
p73 Polyclonal Antibody
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p73 Antibody (PA5-98211) in IHC (P)
Immunohistochemical analysis of p73 in paraffin embedded human cervical cancer using a p73 polyclonal antibody (Product # PA5-98211) at a dilution of 1:100. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detecte... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-98211
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide sequence from Human Tumor protein p73 protein (537-555AA)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.17 mg/mL
规格
17 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
P73 (TP73) participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: OTTHUMP00000003479; OTTHUMP00000003480; p53-like transcription factor; p53-related protein; P73; RP23-254N4.10; Tumor protein p73; unnamed protein product
基因别名: CILD47; P73; TP73
Entrez Gene ID: (Human) 7161
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription corepressor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
p53 binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein kinase binding
identical protein binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
MDM2/MDM4 family protein binding
DNA-binding transcription factor binding
promoter-specific chromatin binding
mismatch repair
regulation of transcription, DNA-templated
apoptotic process
cellular response to DNA damage stimulus
regulation of mitotic cell cycle
negative regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of gene expression
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of apoptotic process
positive regulation of cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
protein tetramerization
regulation of cell cycle
negative regulation of cardiac muscle cell proliferation
positive regulation of lung ciliated cell differentiation
positive regulation of apoptotic signaling pathway
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