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Invitrogen
Human HIPK2, GST Tag Recombinant Protein
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Product Details
PV5275
Product Specifications
Species
Human
Expression System
Baculovirus
Amino acid sequence
165-564
Tag
GST-tag
Molecular weight
73 kDa
Class
Recombinant
Type
Protein
Conjugate
Form
Liquid
Concentration
See Label
Purification
purified
Storage buffer
50mM tris
Contains
no preservative
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
Protein Form: Catalytic
Target Information
The HIPK2 gene encodes a member of the homeodomain-interacting protein kinase family, specifically a serine/threonine nuclear protein kinase. HIPK2 plays versatile roles in cellular processes, including transcription regulation, cell proliferation, differentiation, and apoptosis. It interacts with various transcription factors and proteins, contributing significantly to the modulation of gene expression. Notably, HIPK2 is involved in the activation of the tumor suppressor protein p53, with p53-dependent pro-apoptotic activity, positioning HIPK2 as a potential tumor suppressor gene. Recent studies highlight its downregulation in multiple tumor types and its emerging role in cancer biology and therapy. Its expression is subject to quality control mechanisms, including autophosphorylation at serine and threonine sites. Structurally, the crystal structure of HIPK2 reveals unique conformational attributes that contribute to its functionality in different signaling pathways. HIPK2's influence extends to physiological processes, such as fibrosis and central nervous system regulation, indicating its broad biological significance and potential therapeutic applications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hHIPk2; Homeodomain-interacting protein kinase 2
Gene Aliases: HIPK2; PRO0593
UniProt ID: (Human) Q9H2X6
Entrez Gene ID: (Human) 28996
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