PCDNA6⁄TR, 20UG VIAL
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Citations & References (1)

PCDNA6⁄TR, 20UG VIAL

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Catalog number 351592
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PCDNA6⁄TR, 20UG VIAL
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Citations & References (1)

Citations & References
Abstract
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector.
Authors:van de Wetering M, Oving I, Muncan V, Pon Fong MT, Brantjes H, van Leenen D, Holstege FC, Brummelkamp TR, Agami R, Clevers H,
Journal:EMBO Rep
PubMed ID:12776180
'We have designed a doxycycline-regulated form of the H1 promoter of RNA polymerase III that allows the inducible knockdown of gene expression by small interfering RNAs (siRNAs). As a proof-of-principle, we have targeted beta-catenin in colorectal cancer (CRC) cells. T-cell factor (TCF) target-gene expression is induced by accumulated beta-catenin, and ... More