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Thermo Scientific Chemicals
N-tert-Butyl-alpha-phenylnitrone, 97%
CAS: 3376-24-7 | C11H15NO | 177.247 g/mol
| Catalog Number | Quantity |
|---|---|
| A17442.03 also known as A17442-03 | 1 g |
Chemical Identifiers
CAS3376-24-7
IUPAC NameN-tert-butyl-1-phenylmethanimine oxide
Molecular FormulaC11H15NO
InChI KeyIYSYLWYGCWTJSG-UHFFFAOYSA-N
SMILESCC(C)(C)[N+]([O-])=CC1=CC=CC=C1
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Specifications
Specification Sheet
Specification SheetFormCrystals or powder or crystalline powder
Appearance (Color)White to pale cream
Assay (GC)≥96.0%
Melting Point (clear melt)70.0-78.0°C
N-tert-Butyl-a-phenylnitrone is a commonly-used free radical trap. It contains radical scavenging activity and an ability to inhibit Cox-2 (cyclooxygenase-2). N-tert-Butyl-a-phenylnitrone is an antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. N-tert-Butyl-a-phenylnitrone inhibits lipid peroxidation in rat liver microsomes. It also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
N-tert-Butyl-a-phenylnitrone is a commonly-used free radical trap. It contains radical scavenging activity and an ability to inhibit Cox-2 (cyclooxygenase-2). N-tert-Butyl-a-phenylnitrone is an antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. N-tert-Butyl-a-phenylnitrone inhibits lipid peroxidation in rat liver microsomes. It also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.
Solubility
Soluble in DMSO (10 mg/ml), chloroform (50 mg/ml), and water (20 mg/ml).
Notes
Store in a cool place. Reactive with oxidizing agents.
N-tert-Butyl-a-phenylnitrone is a commonly-used free radical trap. It contains radical scavenging activity and an ability to inhibit Cox-2 (cyclooxygenase-2). N-tert-Butyl-a-phenylnitrone is an antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. N-tert-Butyl-a-phenylnitrone inhibits lipid peroxidation in rat liver microsomes. It also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.
Solubility
Soluble in DMSO (10 mg/ml), chloroform (50 mg/ml), and water (20 mg/ml).
Notes
Store in a cool place. Reactive with oxidizing agents.
RUO – Research Use Only
General References:
- Edward G. Janzen.; C. Anderson Evans. Rate constants for the addition of phenyl radicals to N-(tert-butyl)-.alpha.-phenylnitrone (spin trapping) and benzene (phenylation) as studied by electron spin resonance. J. Am. Chem. Soc. 1975, 97 (1), 205-206.
- Xianghui Cao.; John W. Phillis. α-Phenyl-tert-butyl-nitrone reduces cortical infarct and edema in rats subjected to focal ischemia. Brain Research. 1994, 644 (2), 267-272.
- For examples of 1,3-dipolar cycloaddition reactions, see N,ɑ-Diphenyl nitrone, L00185.