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Citations & References (134)
Invitrogen™
Laurdan (6-Dodecanoyl-2-Dimethylaminonaphthalene)
When the lipophlilic probe laurdan is incorporated into membranes, its fluorescence spectra is sensitive to the physical state of the surrounding phospholipids.
| Catalog Number | Quantity |
|---|---|
| D250 | 100 mg |
Catalog number D250
Price (CNY)
5,938.00
Each
Quantity:
100 mg
Price (CNY)
5,938.00
Each
When the lipophlilic probe laurdan is incorporated into membranes, its fluorescence spectra is sensitive to the physical state of the surrounding phospholipids.
To make a concentrated stock solution of up to 20 mM, dissolve in either DMF or acetonitrile. Store frozen, desiccated and protected from light.
For Research Use Only. Not for use in diagnostic procedures.
Specifications
ColorGreen
Detection MethodFluorescence
For Use With (Equipment)Fluorescence Microscope
Molecular Weight (g/mol)353.55
Quantity100 mg
Shipping ConditionRoom Temperature
Label TypeFluorescent Dye
Product TypeDye
Sub Cellular LocalizationCell Membranes, Lipids
Unit SizeEach
Contents & Storage
Store at room temperature and protect from light.
Frequently asked questions (FAQs)
What is the recommended solvent and concentration for Laurdan (6-Dodecanoyl-2-Dimethylaminonaphthalene) (Cat. No. D250) stock solution?
Citations & References (134)
Citations & References
Abstract
Two-photon fluorescence microscopy observation of shape changes at the phase transition in phospholipid giant unilamellar vesicles.
Journal:Biophys J
PubMed ID:10512829
'Using the sectioning effect of the two-photon fluorescence microscope, we studied the behavior of phospholipid giant unilamellar vesicles (GUVs) composed of pure diacylphosphatidylcholine phospholipids during the gel-to-liquid crystalline phase transition. We used the well-characterized excitation generalized polarization function (GP(ex)) of 6-dodecanoyl-2-dimethylamine-naphthalene (LAURDAN), which is sensitive to the changes in water
Physical properties of erythrocyte ghosts that determine susceptibility to secretory phospholipase A2.
Journal:J Biol Chem
PubMed ID:11294853
'Artificial membranes may be resistant or susceptible to catalytic attack by secretory phospholipase A(2) (sPLA(2)) depending on the physical properties of the membrane. Living cells are normally resistant but become susceptible during trauma, apoptosis, and/or a significant elevation of intracellular calcium. Intact erythrocytes and ghosts were studied to determine whether
Comparative benzene-induced fatty acid changes in a Rhodococcus species and its benzene-sensitive mutant: possible role of myristic and oleic acids in tolerance.
Journal:J Chem Ecol
PubMed ID:14682518
'A Gram positive bacterium of the genus Rhodococcus was isolated from a contaminated site in Sydney, Australia, for its ability to tolerate and degrade high concentrations of benzene. To identify fatty acids that may impart this Rhodococcus sp. with tolerance to toxic solvents, a benzene-sensitive strain, labeled M2b, was isolated
Interactions of Laurdan with phosphatidylcholine liposomes: a high pressure FTIR study.
Journal:Biochim Biophys Acta
PubMed ID:8323945
'The interactions of 6-lauroyl-2-dimethylaminonaphthalene (Laurdan) with L-alpha-dimyristoylphosphatidylcholine (DMPC) have been studied isothermally at 28 degrees C by Fourier-transform infrared spectroscopy (FTIR) at two pH values (6.8 and 3.0) and over the pressure range of 0.001-25 kbar. The results obtained with Laurdan are compared with those previously obtained with 6-propionyl-2-dimethylaminonaphthalene (Prodan)
Lipid rafts reconstituted in model membranes.
Journal:Biophys J
PubMed ID:11222302
'One key tenet of the raft hypothesis is that the formation of glycosphingolipid- and cholesterol-rich lipid domains can be driven solely by characteristic lipid-lipid interactions, suggesting that rafts ought to form in model membranes composed of appropriate lipids. In fact, domains with raft-like properties were found to coexist with fluid