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Citations & References (93)
Invitrogen™
EGTA, Tetra(acetoxymethyl Ester) (EGTA, AM)
The cell-permeant EGTA, AM can be passively loaded into cells to generate intracellular EGTA. This compound is intrinsically a liquidRead more
| Catalog Number | Quantity |
|---|---|
| E1219 | 10 mg |
Catalog number E1219
Price (CNY)
6,642.00
Each
Quantity:
10 mg
Price (CNY)
6,642.00
Each
The cell-permeant EGTA, AM can be passively loaded into cells to generate intracellular EGTA. This compound is intrinsically a liquid or an oil at room temperature.
Learn more about ion indicators including calcium, potassium, pH, and membrane potential indicators ›
Learn more about ion indicators including calcium, potassium, pH, and membrane potential indicators ›
For Research Use Only. Not for use in diagnostic procedures.
Specifications
Dye TypeChelator (Non-Fluorescent)
Quantity10 mg
Shipping ConditionRoom Temperature
Product TypeEGTA AM
Unit SizeEach
Contents & Storage
Store in freezer -5°C to -30°C.
Citations & References (93)
Citations & References
Abstract
Alpha-adducin dissociates from F-actin and spectrin during platelet activation.
Journal:J Cell Biol
PubMed ID:12743105
'Aspectrin-based skeleton uniformly underlies and supports the plasma membrane of the resting platelet, but remodels and centralizes in the activated platelet. alpha-Adducin, a phosphoprotein that forms a ternary complex with F-actin and spectrin, is dephosphorylated and mostly bound to spectrin in the membrane skeleton of the resting platelet at sites
The platelet cytoskeleton regulates the affinity of the integrin alpha(IIb)beta(3) for fibrinogen.
Journal:J Biol Chem
PubMed ID:10464255
'Agonist-generated inside-out signals enable the platelet integrin alpha(IIb)beta(3) to bind soluble ligands such as fibrinogen. We found that inhibiting actin polymerization in unstimulated platelets with cytochalasin D or latrunculin A mimics the effects of platelet agonists by inducing fibrinogen binding to alpha(IIb)beta(3). By contrast, stabilizing actin filaments with jasplakinolide prevented
Feedback inhibition of sodium/calcium exchange by mitochondrial calcium accumulation.
Journal:J Biol Chem
PubMed ID:10801871
'Chinese hamster ovary cells expressing the bovine cardiac Na(+)/Ca(2+) exchanger were subjected to two periods of 5 and 3 min, respectively, during which the extracellular Na(+) concentration ([Na(+)](o)) was reduced to 20 mm; these intervals were separated by a 5-min recovery period at 140 mm Na(+)(o). The cytosolic Ca(2+) concentration
Early cellular events couple covalent binding of reactive metabolites to cell killing by nephrotoxic cysteine conjugates.
Journal:J Cell Physiol
PubMed ID:7525611
'Addition of the nephrotoxic cysteine conjugate, S-(1,2-dichlorovinyl)-L-cysteine (DCVC), to the LLC-PK1 line of renal epithelial cells leads to covalent binding of reactive intermediates followed by thiol depletion, lipid peroxidation, and cell death (Chen et al., 1990, J. Biol. Chem., 265:21603-21611). The present study was designed to determine if increased intracellular
Cell type-specific modes of feedback regulation of capacitative calcium entry.
Journal:J Biol Chem
PubMed ID:8662975
'The Ca2+-ATPase inhibitor, thapsigargin, activated Ca2+ entry into pancreatic acinar cells, a process known as capacitative calcium entry. In cells loaded with the calcium chelator BAPTA, the transient Ca2+ release was blunted and the rise of [Ca2+]i on readdition of Ca2+ was slowed. However, the steady-state [Ca2+]i due to Ca2+