Acriflavine hydrochloride, Thermo Scientific Chemicals

An intercalating dye

Catalog Number	Quantity
J60048.14 also known as J60048-14	25 g

Catalog number J60048.14

also known as J60048-14

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Chemical Identifiers

CAS8063-24-9

IUPAC Name3,6-diamino-10-methylacridin-10-ium acridine-3,6-diamine dihydrochloride chloride

Molecular FormulaC27H27Cl3N6

InChI KeyMKLTXAHQKDVBLY-UHFFFAOYSA-N

SMILESCl.Cl.[Cl-].NC1=CC2=NC3=CC(N)=CC=C3C=C2C=C1.C[N+]1=C2C=C(N)C=CC2=CC2=CC=C(N)C=C12

Specifications

Loss on Drying6.5% max.

Sulfated Ash1.0% max.

Assay (Argentometric Titration)98.5% to 105%

Acriflavine Hydrochloride acts as an intercalating dye and also reported to inhibit mitochondriogenesis. It is an antiseptic and has been used in applications for dual fluorescence analysis of cellular DNA and protein simultaneously.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Acriflavine Hydrochloride acts as an intercalating dye and also reported to inhibit mitochondriogenesis. It is an antiseptic and has been used in applications for dual fluorescence analysis of cellular DNA and protein simultaneously.

Solubility
Soluble in water, dimethyl sulfoxide and methanol.

Notes
A mixture of 3,6-diamino-10-methylacridinium chloride and 3,6-diaminoacridine

RUO – Research Use Only

General References:

Santiago Ramón-García et. al. Functional and genetic characterization of the tap efflux pump in Mycobacterium bovis BCG. Antimicrobial Agents and Chemotherapy, 2012, 56(4), 2074-2083.
Saadia Hassan et. al. Novel activity of acriflavine against colorectal cancer tumor cells. Cancer Science, 2011,102(12), 2206-2213.