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Thermo Scientific Chemicals
2-Iminothiolane hydrochloride
Protein modification and cross-linking reagent, cleavable by thiols | CAS: 4781-83-3 | C4H8ClNS | 137.625 g/mol
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Catalog number J60131.MD
also known as J60131-MD
Price (CNY)
-
Quantity:
250 mg
Chemical Identifiers
CAS4781-83-3
IUPAC Namehydrogen thiolan-2-imine chloride
Molecular FormulaC4H8ClNS
InChI KeyATGUDZODTABURZ-UHFFFAOYSA-N
SMILES[H+].[Cl-].N=C1CCCS1
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Specifications
Specification Sheet
Specification SheetFormPowder
Solution Test100mg/mL in water
Appearance (Color)White
Assay (HPLC)97.0% min.
2-Iminothiolane hydrochloride is predominantly used as an amine reactive at pH 7-10 and is also an effective thiolation reagent for polysaccharides. It is also used as a RNA-protein crosslinking reagent as well as useful in cross-linking proteins..
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
2-Iminothiolane hydrochloride is predominantly used as an amine reactive at pH 7-10 and is also an effective thiolation reagent for polysaccharides. It is also used as a RNA-protein crosslinking reagent as well as useful in cross-linking proteins..
Solubility
Freely soluble in water
Notes
Protect from moisture. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away fom strong oxidizing agents.
2-Iminothiolane hydrochloride is predominantly used as an amine reactive at pH 7-10 and is also an effective thiolation reagent for polysaccharides. It is also used as a RNA-protein crosslinking reagent as well as useful in cross-linking proteins..
Solubility
Freely soluble in water
Notes
Protect from moisture. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away fom strong oxidizing agents.
RUO – Research Use Only
General References:
- A Bernkop-Schnürch.; M Hornof.; T Zoidl. Thiolated polymers—thiomers: synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates. International Journal of Pharmaceutics. 2003, 260,(2), 229-237.
- R Jue.; JM Lambert.; LR Pierce.; RR Traut. Addition of sulfhydryl groups of Escherichia coli ribosomes by protein modification with 2-iminothiolane (methyl 4-mercaptobutyrimidate). Biochemistry. 1978, 17,(25), 5399-5406.