Meclofenamic acid sodium salt, 99+%

Name: Meclofenamic acid sodium salt, 99+%
SKU: J60484.06

Meclofenamic acid (meclofenamate, CAS # 644-62-2) is a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic and antineoplastic activities. | CAS: 6385-02-0 | C14H13Cl2NNaO2 | 321.153 g/mol

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Catalog number J60484.06

also known as J60484-06

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5 g

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Specifications

CAS6385-02-0

Chemical Name or MaterialMeclofenamic acid sodium salt

ColorWhite

EINECS Number228-983-3

Formula Weight318.13

Inhibits 5-lipoxygenase and cyclooxygenase; NSAID

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Meclofenamic acid is an aminobenzoic acid-based NSAID that is characterized by two aryl moieties

• Meclofenamic acid is an inhibitor of arachidonate 5-lipoxygenase and prostaglandin-endoperoxide synthase

• Meclofenamic acid prevents pyrogen release and inhibits wound granulation; it may also act as a neoplastic

Application

• Meclofenamic acid can complex metals, making it of interest to drug delivery studies that target its toxic metal complexes to cancerous cell types

• It is suitable for laboratory research on pain, degeneration, wound healing, and tumor growth

RUO – Research Use Only

General References:

Soriano-Hernández AD, Galvan-Salazar HR, Montes-Galindo DA, Rodriguez-Hernandez A, Martinez-Martinez R, Guzman-Esquivel J, Valdez-Velazquez LL, Baltazar-Rodriguez LM, Espinoza-Gómez F, Rojas-Martinez A, Ortiz-Lopez R, Gonzalez-Alvarez R, Delgado-Enciso I. Antitumor effect of meclofenamic acid on human androgen-independent prostate cancer: a preclinical evaluation. Int Urol Nephrol. 2012 Apr;44(2):471-7. doi: 10.1007/s11255-011-0012-0. Epub 2011 Jun 10. PMID: 21660425.
Saigo C, Nomura Y, Yamamoto Y, Sagata M, Matsunaga R, Jono H, Nishi K, Saito H. Meclofenamate elicits a nephropreventing effect in a rat model of ischemic acute kidney injury by suppressing indoxyl sulfate production and restoring renal organic anion transporters. Drug Des Devel Ther. 2014 Aug 13;8:1073-82. doi: 10.2147/DDDT.S67456. PMID: 25143712; PMCID: PMC4137993.