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Dextran, MW ca 75,000

Name: Dextran, MW ca 75,000
SKU: J60989.22

Dextran, CAS # 9004-54-0, is a glucose polymer. It is mainly used to increase electronegativity and reduce erythrocyte aggregation and platelet adhesiveness (anticoagulant activity). | CAS: 9004-54-0 | (C6H9O5)n(C6H10O5)m | 504.44 g/mol

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Catalog number J60989.22

also known as J60989-22

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Quantity:

100 g

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Chemical Identifiers

CAS9004-54-0

IUPAC NameDextran

Molecular Formula(C6H9O5)n(C6H10O5)m

SMILESO[C@@H]1[C@@H](O)[C@@H](-*)O[C@H](CO[C@H]2O[C@H](CO-*)[C@@H](O)[C@H](O-*)[C@H]2O)[C@H]1O

MDL NumberMFCD00130935

Specifications

Specification Sheet

Solution TestCold water solubility (1%): Soluble

ViscosityIntrinsic viscosity (1% solution at 37?C): 0.22 to 0.27

FormWhite to off white powder

Ash≤ 2%

pH4.5 to 7. 0 (6% solution)

Dextran, MW ca 75,000 is used as a processing aid, stabilizer, thickener, and surface finishing agent.. Further, it is used in soft center confections. In addition to this, it is used as a barley malt substitute and as a plasma volume expander.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Dextran is a glucose polymer biosynthesized by the non-pathogenic Leuconostoc mesenteroides

Application

• Dextran is a complex branched glucan that can be used to enhance electronegativity and reduce erythrocyte aggregation and platelet adhesiveness (anticoagulant activity)

• This compound promotes the activation of plasminogen by inhibiting α-2 antiplasmin

• Dextran can be used to reduce thrombosis in animal models

• It is used in osmotic stress techniques where osmotic pressure is applied to biological molecules • Dextran can be used as an immobilization agent in biosensors

RUO – Research Use Only

General References:

Zhang, Z.; Amorosa, L. F.; Coyle, S. M.; Macor, M. A.; Lubitz, S. E.; Carson, J. L.; Birnbaum, M. J.; Lee, L. Y.; Haimovich, B. Proteolytic Cleavage of AMPK alpha and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1alpha Expression in Leukocytes. J. Immunol. 2015, 195 (5), 2452-2460.
Kim, N. H.; Pham, N. B.; Quinn, R. J.; Shim, J. S.; Cho, H.; Cho, S. M.; Park, S. W.; Kim, J. H.; Seok, S. H.; Oh, J. W.; Kwon, H. J. The Small Molecule R-(-)-beta-O-Methylsynephrine Binds to Nucleoporin 153 kDa and Inhibits Angiogenesis. Int J Biol Sci. 2015, 11 (9), 1088-1099.