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Thermo Scientific Chemicals
Alendronate sodium trihydrate, 97%
CAS: 121268-17-5 | C4H18NNaO10P2 | 325.122 g/mol
| Catalog Number | Quantity |
|---|---|
| J61397.06 also known as J61397-06 | 5 g |
Chemical Identifiers
CAS121268-17-5
IUPAC Namesodium trihydrate hydrogen (4-amino-1-hydroxy-1-phosphonobutyl)phosphonate
Molecular FormulaC4H18NNaO10P2
InChI KeyDCSBSVSZJRSITC-UHFFFAOYNA-M
SMILESO.O.O.[Na+].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O
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Specifications
Specification Sheet
Specification SheetFormPowder or crystals or crystalline powder
Identification (FTIR)Conforms
Assay from Supplier's CofA≥96.0%
Appearance (Color)White to pale cream
Loss on Drying14.0-19.0%
Alendronate sodium trihydrate is used as a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor and CD45 protein tyrosine phosphatase inhibitor. A robust inhibitor of bone resorption that induces apoptosis. Alendronate inhibits the migration and invasion of PC-3 cells (sc-2220) by interfering with the mevalonate pathway. Additionally, Alendronate, Sodium Salt is an inhibitor of CD45RC and MMP.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Alendronate sodium trihydrate is used as a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor and CD45 protein tyrosine phosphatase inhibitor. A robust inhibitor of bone resorption that induces apoptosis. Alendronate inhibits the migration and invasion of PC-3 cells (sc-2220) by interfering with the mevalonate pathway. Additionally, Alendronate, Sodium Salt is an inhibitor of CD45RC and MMP.
Solubility
Soluble in water at 10mg/ml
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents.
Alendronate sodium trihydrate is used as a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor and CD45 protein tyrosine phosphatase inhibitor. A robust inhibitor of bone resorption that induces apoptosis. Alendronate inhibits the migration and invasion of PC-3 cells (sc-2220) by interfering with the mevalonate pathway. Additionally, Alendronate, Sodium Salt is an inhibitor of CD45RC and MMP.
Solubility
Soluble in water at 10mg/ml
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents.
RUO – Research Use Only
General References:
- Osama Hussein et. al. Breast cancer cells inhibit spontaneous and bisphosphonate-induced osteoclast apoptosis. Bone . 2011, 48, (2), 202-211 .
- Minakshi Asnani et. al. Ab initio structure determination of anhydrous sodium alendronate from laboratory powder X-ray diffraction data. Journal of Pharmaceutical Sciences. 2009, 98, (6), 2113-2121.