L-Glutathione, reduced, 98+%
L-Glutathione, reduced, 98+%
L-Glutathione, reduced, 98+%
Thermo Scientific Chemicals

L-Glutathione, reduced, 98+%

A tripeptide used for reductive cleavage of disulfide bonds | CAS: 70-18-8 | C10H17N3O6S | 307.321 g/mol
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Catalog number J62166.14
also known as J62166-14
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25 g
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Chemical Identifiers
CAS70-18-8
IUPAC Name2-amino-4-({1-[(carboxymethyl)carbamoyl]-2-sulfanylethyl}carbamoyl)butanoic acid
Molecular FormulaC10H17N3O6S
InChI KeyRWSXRVCMGQZWBV-UHFFFAOYNA-N
SMILESNC(CCC(=O)NC(CS)C(=O)NCC(O)=O)C(O)=O
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)White
FormCrystalline powder
Assay from Supplier's CofA≥98.0%
Heavy Metals≤10 ppm
Residue on ignition≤0.1%
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A tripeptide used for the reductive cleavage of disulfide bonds L-Glutathione is used in the treatment of lung diseases for patients who are HIV positive. It protects the cancerous cells by conferring resistance to chemotherapeutic drugs. It is involved in many aspects of metabolism including transport of g-glutanyl amino acids and reductive cleavage of disulfide bonds. As an antioxidant, it prevents damage to important cellular components that arise due to reactive oxygen species like free radicals and peroxide. It is also used to decrease the concentrations of inflammatory cytokines (IL-6, IL-18) as well as involved in increasing the level of serum Ca2+ ions. It is also used in white wine production.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in water, dimethyl formamide, ethanol, phosphate buffered saline, diluted alcohol, liquid ammonia and dimethyl sulfoxide.

Notes
Store in cool place. Incompatible with strong oxidizing agents.
RUO – Research Use Only

General References:

  1. Deheshi, S.; Dabiri, B.; Fan, S.; Tsang, M.; Rintoul, G. L. Changes in mitochondrial morphology induced by calcium or rotenone in primary astrocytes occur predominantly through ros-mediated remodeling. J. Neurochem. 2015, 133 (5), 684-699.
  2. Li, X.; Zheng, L.; Wang, Y.; Zhang, N.; Lou, Y.; Xiao, T.; Liu, J. A novel electrocatalyst with high sensitivity in detecting glutathione reduced by 2-hydroxypropyl- β-cyclodextrin enveloped 10-methylphenothiazine. RSC Adv. 2015, 5 (88), 71749-71755.