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Amiloride hydrochloride dihydrate
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Amiloride hydrochloride dihydrate
Amiloride hydrochloride dihydrate
Amiloride hydrochloride dihydrate
Thermo Scientific Chemicals

Amiloride hydrochloride dihydrate

Sodium channel blocker | CAS: 17440-83-4 | C6H13Cl2N7O3 | 302.116 g/mol
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Catalog number J62168.03
also known as J62168-03
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1 g
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Chemical Identifiers
CAS17440-83-4
IUPAC Namehydrogen 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide dihydrate chloride
Molecular FormulaC6H13Cl2N7O3
InChI KeyLTKVFMLMEYCWMK-UHFFFAOYSA-N
SMILES[H+].O.O.[Cl-].NC(N)=NC(=O)C1=NC(Cl)=C(N)N=C1N
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SpecificationsSpecification SheetSpecification Sheet
Assay (HPLC)98.0% min.
Water Content (Karl Fischer Titration)16.9% max.

Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 ?M. Amiloride

  • HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 μM. Amiloride • HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.

Solubility
Soluble in water at 50mg/ml

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
RUO – Research Use Only

General References:

  1. Vassalli et al. Amiloride selectively inhibits the urokinase-type plasminogen activator. FEBS Lett.1987, 214, (1), 187-91.
  2. Kleyman et al. Amiloride and its analogues as tools in the study of ion transport. J.Membr.Biol.1988, 105, (1), 1-21.