Cyclosporin A, 99+%

Name: Cyclosporin A, 99+%
SKU: J63191.06

Cyclosporin A, CAS # 59865-13-3, is a compound that shows immunosuppressive, antifungal, antirheumatic, and dermatologic activities. It is also a calcineurin and enzyme inhibitor. | CAS: 59865-13-3 | C62H111N11O12 | 1202.64 g/mol

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5 g

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Catalog number J63191.06

also known as J63191-06

Price (CNY)

Quantity:

5 g

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Chemical Identifiers

CAS59865-13-3

Specifications

Specification Sheet

Appearance (Color)White

Assay from Suppliers CofA≥99.0%

FormPowder or crystals or crystalline powder

Ciclosporin A induces apoptosis and inhibits angiogenesis induced by VEGF. It also suppresses the replication of hepatitis C virus genome in cultured hepatocytes.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum

Applications

It inhibits phosphoprotein phosphatase
Cyclosporin A binds to the cellular protein cytophilin and inhibits the enzyme calcineurin
Furthermore, it can induce apoptosis and inhibit angiogenesis induced by VEGF
It exerts potent immunosuppressive activity on T immune cells, and causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle
It also suppresses the hepatitis C virus replication in cultured hepatocytes

RUO – Research Use Only

General References:

Staudinger, L. A.; Spano, S. J.; Lee, W. S.; Coelho, N.; Moriarty, T. J.; McCulloch, C. A. Role of discoidin domain receptor 1 in dysregulation of collagen remodeling by cyclosporin A. Int. J. Biochem. Cell Biol. 2015, 62, 80-87.
Petrillo, C.; Cesana, D.; Piras, F.; Bartolaccini, S.; Naldini, L.; Montini, E.; Rudnitski, A. K. Cyclosporin A and Rapamycin Relieve Distinct Lentiviral Restriction Blocks in Hematopoietic Stem and Progenitor Cells. Molecular Therapy 2015, 23 (2), 352-362.