3-Isobutyl-1-methylxanthine

CAS: 28822-58-4 | C10H14N4O2 | 222.25 g/mol

Catalog Number	Quantity
J64598.MC also known as J64598-MC	100 mg

Catalog number J64598.MC

also known as J64598-MC

Price (CNY)

Quantity:

100 mg

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Chemical Identifiers

CAS28822-58-4

IUPAC Name1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione

Molecular FormulaC10H14N4O2

InChI KeyAPIXJSLKIYYUKG-UHFFFAOYSA-N

SMILESCC(C)CN1C2=C(NC=N2)C(=O)N(C)C1=O

Specifications

Proton NMRIdentify determined by 1H NMR

FormSolid

Purity≥98.0%

Appearance (Color)White

3-Isobutyl-1-methylxanthine is used in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the growth of carcinoma cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
3-Isobutyl-1-methylxanthine is used in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction.

RUO – Research Use Only

General References:

Stephen C. Mann.; Paul A. Andrews.; Stephen B. Howell. Modulation of cis-diamminedichloroplatinum(II) accumulation and sensitivity by forskolin and 3-isobutyl-1-methylxanthine in sensitive and resistant human ovarian carcinoma cells. International Journal of Cancer. 1991, 48, (6), 866-872.
Friedman, G.; Chajek-Shaul, T.; Stein, O.; Stein, Y. Modulation of lipoprotein lipase activity in cultured rat mesenchymal heart cells and preadipocytes by dibutyryl cyclic amp, cholera toxin and 3-isobutyl- 1-methylxanthine. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1983, 752, (1), 106-117.