SB 225002

A potent, selective and competitive antagonist of the G-protein coupled receptor CXCR2

Catalog Number	Quantity
J65387.MA also known as J65387-MA	10 mg

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Catalog number J65387.MA

also known as J65387-MA

Price (CNY)

Quantity:

10 mg

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Chemical Identifiers

CAS182498-32-4

IUPAC Name3-(2-bromophenyl)-1-(2-hydroxy-4-nitrophenyl)urea

Molecular FormulaC13H10BrN3O4

InChI KeyMQBZVUNNWUIPMK-UHFFFAOYSA-N

SMILESOC1=C(NC(=O)NC2=CC=CC=C2Br)C=CC(=C1)[N+]([O-])=O

Specifications

Appearance (Color)Pale yellow to yellow

Assay from Supplier's CofA≥95.0%

FormPowder or crystals or crystalline powder

SB 225002 is a selective non-peptide CXCR2 inhibitor which suppresses IL-8 induced neutrophil chemotaxis and margination. In addition, SB 225002 reduces MPO activity, IL-1β, MIP-2, and keratinocyte-derived chemokine (KC) levels. Further studies suggest that SB 225002 decreases the expression of vascular endothelial growth factor, inducible NOS (NO synthase), and Cox-2 (cyclooxygenase-2 proteins) in colon tissue.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

RUO – Research Use Only

Contents & Storage

-30°C to -10°C