Trimethoprim lactate, 98%

Trimethoprim, CAS # 738-70-5, is a trimethoxybenzyl-pyrimidine used as an antimicrobial. | CAS: 23256-42-0 | C17H24N4O6 | 380.401 g/mol

Catalog Number	Quantity	Packaging
J66646.MD	250 mg	Plastic Bottle

This chemical may require us to obtain additional information for our regulatory and chemical compliance records. If required, we will contact you for this information once your order is placed.

Catalog number J66646.MD

Price (CNY)

Quantity:

250 mg

Packaging:

Plastic Bottle

Request bulk or custom format

Chemical Identifiers

CAS23256-42-0

IUPAC Name2-hydroxypropanoic acid; 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine

Molecular FormulaC17H24N4O6

InChI KeyIIZVTUWSIKTFKO-UHFFFAOYNA-N

SMILESCC(O)C(O)=O.COC1=CC(CC2=CN=C(N)N=C2N)=CC(OC)=C1OC

Specifications

Assay (unspecified)97.5% min.

A broad spectrum antibiotic

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Trimethoprim is a synthetic pyrimidine analog that binds dihydrofolate-reductase and inhibits the synthesis of folic acid; when paired with sulfamethoxazole, its activity is enhanced

• Trimethoprim has antibacterial and antiprotozoal properties

Applications

• Trimethoprim inhibits the conversion of para-aminobenzoic acid (PABA) to folic acid near the end of the synthesis pathway and can be used to study related effects

• Trimethoprim has been radiolabeled and used to trace routes of infection, and it also has been used experimentally as a fluorescent labeler to quantify dihydrofolate-reductase expression

RUO – Research Use Only

General References:

De Smet, J.; Croubels, S.; De Backer, P.; Devreese, M. Effect of administration route and dose alteration on sulfadiazine-trimethoprim plasma and intestinal concentrations in pigs. Int J Antimicrob Agents. 2017, 50(6), 707-714.
Ma, R.; Wang, Y.; Zou, X.; Hu, K.; Sun, B.; Fang, W.; Fu G, Yang X. Pharmacokinetics of sulfamethoxazole and trimethoprim in Pacific white shrimp, Litopenaeus vannamei, after oral administration of single-dose and multiple-dose. Environ Toxicol Pharmacol. 2017, 52, 90-98.