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Semi-quantitatively measure auto-antibodies to human thyroid microsomal antigen using Thermo Scientific™ Remel™ Thymune™M Haemagglutination Test. This test is based upon Boyden’s passive haemagglutination system, first used for detection of thyroglobulin antibodies by Witebsky and Rose7. It has been established that auto-antibodies to several different thyroid constituents1,4 are associated with destructive inflammatory lesions of the thyroid gland. Antibodies to these constituents, namely thyroglobulin and the microsomal antigen, are of particular importance for diagnostics purposes3,5,6.
Description | Thymune-M |
CE Marker | Yes |
Quantity | 50 Tests/Kit |
Unit Size | Each |
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Thyroglobulin haemagglutination tests give useful predictive evidence of possible thyroid dysfunction in patients with other autoimmune endocrine disorders such as Addison’s disease, insulin-dependent diabetes mellitus or polyendocrine autoimmunopathies, and in members of families prone to organspecific autoimmunity. The antibodies detected by the microsomal haemagglutination test are the principal circulating marker of human autoimmune thyroid disease.
The purified microsomal antigen is isolated from human thyrotoxic glands. The microsomal fraction is then bound to the surface of turkey erythrocytes2 which have been treated with tannic acid and these “sensitised” cells will agglutinate in the presence of specific autoantibodies. A small proportion of human sera are reactive against turkey cells, giving rise to non-specific agglutination of the sensitised cells. These non-specific reactions may be detected by means of unsensitised control cells. Both test and control cells are treated with formalin and freeze-dried to give long term stability on storage.
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Remel™ and Oxoid™ products are now part of the Thermo Scientific brand.