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Citations & References (400)
Invitrogen™
JC-1 Dye (Mitochondrial Membrane Potential Probe)
JC-1 is a novel cationic carbocyanine dye that accumulates in mitochondria. The dye exists as a monomer at low concentrationsRead more
| Catalog Number | Quantity |
|---|---|
| T3168 | 5 mg |
Catalog number T3168
Price (CNY)
6,648.00
飞享价
Ends: 31-Dec-2025
9,012.00Save 2,364.00 (26%)
5 mg
Quantity:
5 mg
Price (CNY)
6,648.00
飞享价
Ends: 31-Dec-2025
9,012.00Save 2,364.00 (26%)
5 mg
JC-1 is a novel cationic carbocyanine dye that accumulates in mitochondria. The dye exists as a monomer at low concentrations and yields green fluorescence, similar to fluorescein. At higher concentrations, the dye forms J-aggregates that exhibit a broad excitation spectrum and an emission maximum at ∼590 nm. These characteristics make JC-1 a sensitive marker for mitochondrial membrane potential. Another dye with similar characteristics is JC-9 (D-22421).
Given that JC-1 and JC-9 dyes are mitochondrial membrane potential indicators, they are designed to be used in live cells with active mitochondria. These dyes are not compatible with fixed cell staining.
Visualize staining your cell without wasting your reagents, antibodies, or time with our new Stain-iT Cell Staining Simulator.
Given that JC-1 and JC-9 dyes are mitochondrial membrane potential indicators, they are designed to be used in live cells with active mitochondria. These dyes are not compatible with fixed cell staining.
Visualize staining your cell without wasting your reagents, antibodies, or time with our new Stain-iT Cell Staining Simulator.
For Research Use Only. Not for use in diagnostic procedures.
Specifications
Detection MethodFluorescence
Quantity5 mg
Shipping ConditionRoom Temperature
Sub Cellular LocalizationMitochondria
ColorGreen
For Use With (Equipment)Fluorescence Microscope, Flow Cytometer
Product TypeDye
Unit Size5 mg
Contents & Storage
Store at room temperature and protect from light.
Frequently asked questions (FAQs)
I am seeing high background outside of my neuronal cells when using membrane potential indicators. What can I do to reduce background?
What is the difference between fast and slow-response membrane potential probes?
What type of membrane potential indicators do you offer and how should I choose one for my experiment?
Citations & References (400)
Citations & References
Abstract
Apoptosis induced by Rac GTPase correlates with induction of FasL and ceramides production.
Journal:Molecular biology of the cell
PubMed ID:11102528
Rho proteins, members of the Ras superfamily of GTPases, are critical elements in signal transduction pathways governing cell proliferation and cell death. Different members of the family of human Rho GTPases, including RhoA, RhoC, and Rac1, participate in the regulation of apoptosis in response to cytokines and serum deprivation in
Large-scale chemical dissection of mitochondrial function.
Journal:Nature biotechnology
PubMed ID:18297058
Mitochondrial oxidative phosphorylation (OXPHOS) is central to physiology and disease pathogenesis. To systematically investigate its activity and regulation, we performed a wide range of assays of OXPHOS physiology and nuclear and mitochondrial gene expression across 2490 chemical perturbations in muscle cells. Through mining of the resulting compendium, we discovered that:
Journal:
PubMed ID:10891486
Mitochondria--potential role in cell life and death.
Journal:Cardiovascular research
PubMed ID:10727650
The mitochondrial death/life regulator in apoptosis and necrosis.
Journal:Annual review of physiology
PubMed ID:9558479
Both physiological cell death (apoptosis) and, in some cases, accidental cell death (necrosis) involve a two-step process. At a first level, numerous physiological and some pathological stimuli trigger an increase in mitochondrial membrane permeability. The mitochondria release apoptogenic factors through the outer membrane and dissipate the electrochemical gradient of the