Vanquish™ Amplify UHPLC systems

Designed for demanding biopharmaceutical workflows, including oligonucleotide, mRNA, protein therapeutics, and antibody-drug conjugate analysis, the system’s inert sample path helps prevent unwanted interactions between analytes and metal surfaces, reducing adsorption and supporting improved recovery, reproducibility, and confidence in chromatographic results; run after run, what you see isn’t just what you get. It’s what you can depend on. Vanquish™ Amplify UHPLC systems integrate with Thermo Scientific™ SurePac™ RP MDi columns, the Thermo Scientific™ OrbitrapTM Excedion™ mass spectrometer, and Thermo Scientific™ Chromeleon™ CDS software to support LC–MS workflows, compliant data management, and dependable results from early research through manufacturing QC.

Minimize non-specific adsorption of metal-sensitive analytes such as oligonucleotides and RNA, improving recovery, peak shape, reproducibility, and reducing metal adduct formation.

Secure & leak-free fluidic connections through a built-in torque control mechanism ensuring consistent and easy installation that you can hear and feel, preventing over- and under-tightened connections.

Supports demanding high-resolution separations for oligonucleotides and nucleic acids on modern UHPLC methods.

Supports maximized sample volume utilization by enabling the sample draw right from the bottom of the sample container and improved workflow reliability by removing the uncertainty of which settings to use, preventing needle damage.