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引用和文献 (5)
Thermo Scientific™
EGS（乙二醇双(琥珀酰亚胺琥珀酸酯)）
Thermo Scientific Pierce EGS 是一种交联剂，含有位于 12原子间隔臂周围的胺反应性 NHS 酯末端，其可通过在 pH 值了解更多信息
| 货号 | 数量 |
|---|---|
| 21565 | 1 g |
货号 21565
价格（CNY)
4,307.00
Each
数量:
1 g
价格（CNY)
4,307.00
Each
Thermo Scientific Pierce EGS 是一种交联剂，含有位于 12原子间隔臂周围的胺反应性 NHS 酯末端，其可通过在 pH 值 8.5 时使用羟胺处理进行裂解。
EGS 交联剂的特点：
•反应性基团：NHS 酯（两端）
•可与以下基团发生反应：氨基（伯胺）
•不溶于水（首先溶于 DMF 或 DMSO）；与 Sulfo-EGS 具有可比性
•膜可透过性，可进行细胞内交联
•在 pH 值为 8.5 时于 37°C 下使用羟胺处理持续 3 至 6 小时，形成的交联是可逆的
• 乳糖脱氢酶在与 EGS 可逆交联后保持 60% 的活性
产品参考：
交联剂应用指南 - 检索本产品的最新参考文献
相关产品
EGS（乙二醇双(琥珀酰亚胺琥珀酸酯)）
EGS 交联剂的特点：
•反应性基团：NHS 酯（两端）
•可与以下基团发生反应：氨基（伯胺）
•不溶于水（首先溶于 DMF 或 DMSO）；与 Sulfo-EGS 具有可比性
•膜可透过性，可进行细胞内交联
•在 pH 值为 8.5 时于 37°C 下使用羟胺处理持续 3 至 6 小时，形成的交联是可逆的
• 乳糖脱氢酶在与 EGS 可逆交联后保持 60% 的活性
产品参考：
交联剂应用指南 - 检索本产品的最新参考文献
相关产品
EGS（乙二醇双(琥珀酰亚胺琥珀酸酯)）
仅供科研使用。不可用于诊断程序。
规格
细胞渗透性是
描述EGS
形式粉末
标记方法化学标记
分子量456.36
聚乙二醇化否
产品线Pierce
数量1 g
反应一部分NHS 酯
运输条件环境
溶解度DMF、DMSO
间隔臂长16.1 Å
水溶性否
化学反应性胺-胺
可裂解通过羟胺
交联剂类型同型双功能团试剂
产品规格标准
产品类型交联剂
间隔子中等（10 至 30 Å）
Unit SizeEach
内容与储存
接收后，储存在 4°C 下。
常见问题解答 (FAQ)
Can you provide the shelf-life for EGS (ethylene glycol bis(succinimidyl succinate))?
Can NHS-diazirine (Cat. No. 26167) be used for CHIP applications?
引用和文献 (5)
引用和文献
Abstract
Oligomerization of the mitochondrial protein voltage-dependent anion channel is coupled to the induction of apoptosis.
Journal:Mol Cell Biol
PubMed ID:20937774
'Accumulating evidence implicates that the voltage-dependent anion channel (VDAC) functions in mitochondrion-mediated apoptosis and as a critical player in the release of apoptogenic proteins, such as cytochrome c, triggering caspase activation and apoptosis. The mechanisms regulating cytochrome c release and the molecular architecture of the cytochrome c-conducting channel remain unknown.
Structure-based analysis of VDAC1 protein: defining oligomer contact sites.
Journal:J Biol Chem
PubMed ID:22117062
'The outer mitochondrial membrane protein, the voltage-dependent anion channel (VDAC), is increasingly implicated in the control of apoptosis. Oligomeric assembly of VDAC1 was shown to be coupled to apoptosis induction, with oligomerization increasing substantially upon apoptosis induction and inhibited by apoptosis blockers. In this study, structure- and computation-based selection of
Integrated genome-wide analysis of transcription factor occupancy, RNA polymerase II binding and steady-state RNA levels identify differentially regulated functional gene classes.
Journal:Nucleic Acids Res
PubMed ID:21914722
'Routine methods for assaying steady-state mRNA levels such as RNA-seq and micro-arrays are commonly used as readouts to study the role of transcription factors (TFs) in gene expression regulation. However, cellular RNA levels do not solely depend on activity of TFs and subsequent transcription by RNA polymerase II (Pol II),
LXRa regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8.
Journal:Circ Res
PubMed ID:21757649
Activation of liver X receptors (LXRs) inhibits the progression of atherosclerosis and promotes regression of existing lesions. In addition, LXRa levels are high in regressive plaques. Macrophage arginase 1 (Arg1) expression is inversely correlated with atherosclerosis progression and is markedly decreased in foam cells within the lesion.
Resveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation.
Journal:J Biol Chem
PubMed ID:21712378
Resveratrol, a naturally occurring phytoalexin, is known to induce apoptosis in multiple cancer cell types, but the underlying molecular mechanisms remain unclear. Here, we show that resveratrol induced p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated translocation of Bax to mitochondria where it underwent oligomerization to initiate apoptosis. Resveratrol treatment promoted