Isoform-specific up-regulation by ouabain of Na+,K+-ATPase in cultured rat astrocytes.
Authors:Hosoi R, Matsuda T, Asano S, Nakamura H, Hashimoto H, Takuma K, Baba A
Journal:J Neurochem
PubMed ID:9349566
There are two alpha-subunit isoforms (alpha1 and alpha2) and two beta-subunit isoforms (beta1 and beta2) of Na+,K+-ATPase in astrocytes, but the functional heterodimer composition is not known. Ouabain (0.5-1.0 mM) increased the levels of alpha1 and beta1 mRNAs, whereas it decreased those of alpha2 and beta2 mRNAs in cultured rat ... More