Glibenclamide prevents increased extracellular matrix formation induced by high glucose concentration in mesangial cells.
Authors:Giannico G, Cortes P, Baccora MH, Hassett C, Taube DW, Yee J
Journal:Am J Physiol Renal Physiol
PubMed ID:16896180
'Other than stimulation of cell contractility, little is known about the potential metabolic effects induced by sulfonylureas, independently of insulin action. Previous studies from our laboratory demonstrated complete abrogation of glomerulosclerosis in an experimental model of type 1 diabetes chronically (9 mo) treated with low-dose sulfonylureas (Biederman JI, Vera E, ... More