TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent.
Authors:West MA, Prescott AR, Chan KM, Zhou Z, Rose-John S, Scheller J, Watts C,
Journal:J Cell Biol
PubMed ID:18762577
Toll-like receptor (TLR) signaling induces a rapid reorganization of the actin cytoskeleton in cultured mouse dendritic cells (DC), leading to enhanced antigen endocytosis and a concomitant loss of filamentous actin-rich podosomes. We show that as podosomes are lost, TLR signaling induces prominent focal contacts and a transient reduction in DC ... More