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引用和文献 (57)
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甲氨蝶呤荧光素三铵盐（荧光素甲氨蝶呤）
发绿色荧光的荧光素甲氨蝶呤（最大吸收⁄发射波长为 ∼496⁄516 nm）可用于通过荧光显微镜检查或流式细胞分析探测二氢叶酸还原酶 (DHFR) 表达情况。了解更多信息
| 货号 | 数量 |
|---|---|
| M1198MP | 1 mg |
货号 M1198MP
价格（CNY)
5,705.00
Each
数量:
1 mg
价格（CNY)
5,705.00
Each
发绿色荧光的荧光素甲氨蝶呤（最大吸收⁄发射波长为 ∼496⁄516 nm）可用于通过荧光显微镜检查或流式细胞分析探测二氢叶酸还原酶 (DHFR) 表达情况。
仅供科研使用。不可用于诊断程序。
规格
标签类型经典染料
分子式C46H54N14O9S
数量1 mg
建议的储存条件在冷冻冰箱（-5°C 至 -30°C）中避光储存。
运输条件室温
物理形态实心
产品类型三铵盐
Unit SizeEach
引用和文献 (57)
引用和文献
Abstract
Xenobiotic transport across isolated brain microvessels studied by confocal microscopy.
Journal:Molecular pharmacology
PubMed ID:11093774
Visualization of membrane-associated folate transport proteins.
Journal:Adv Enzyme Regul
PubMed ID:2516406
'Transport of Methotrexate (MTX) into cells, via the "reduced folate" transport system, is a critical factor in the effectiveness of the drug in cancer chemotherapy, and defective transport is one of the principal types of resistance to MTX. Probes capable of detecting membrane-associated folate transport proteins (ftp''s) in individual cells
MRP2 and acquired tolerance to inorganic arsenic in the kidney of killifish (Fundulus heteroclitus).
Journal:Toxicol Sci
PubMed ID:17324950
'We used proximal tubules isolated from the killifish, Fundulus heteroclitus, to examine the effect of environmentally relevant, sublethal levels of arsenic on the function and expression of MRP2, an ABC transporter that transports xenobiotics into urine, including arsenic-glutathione conjugates. Exposure of fish to arsenic as sodium arsenite (4-14 days) increased
Characterization of a lipophilic antifolate resistance provoked by treatment of mammalian cells with the antiparasitic agent pyrimethamine.
Journal:J Biol Chem
PubMed ID:8440739
'We describe the characterization of an antitumor drug resistance following multiple step selection of hamster cells to the 2,4-diaminopyrimidines (DAP) metoprine, pyrimethamine (Pyr), and trimethoprim (Tmp). Pyr and Tmp are DAP lipophilic antifolates currently used as antiparasitic and antibacterial antibiotics, respectively. Dihydrofolate reductase (DHFR) from hamster cells bore a low
Defective transport as a mechanism of acquired resistance to methotrexate in patients with acute lymphocytic leukemia.
Journal:Blood
PubMed ID:1381235
'Although the mechanisms of resistance to methotrexate (MTX) are known in experimental tumors made resistant to this drug, little information is available regarding acquired resistance to MTX in patients. A competitive displacement assay using the fluorescent lysine analogue of MTX, N-(4-amino-4-deoxy-N10-methylpteroyl)-N epsilon-(4''-fluorescein-thiocarbamyl)-L-lysine (PT430), was developed as a sensitive method of