TRPV1 regulators mediate gentamicin penetration of cultured kidney cells.
Authors:Myrdal SE, Steyger PS
Journal:Hear Res
PubMed ID:15925202
'Transient receptor potential (TRP) receptors are, typically, calcium-permeant cation channels that transduce environmental stimuli. Both kidney epithelial and inner ear sensory cells express TRPV1, are mechanosensors and accumulate the aminoglycoside antibiotic gentamicin. Recently, we showed that Texas Red-conjugated gentamicin (GTTR) enters kidney cells via an endosome-independent pathway. Here, we used ... More