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Invitrogen
GABRB3 Monoclonal Antibody (N87/25)
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FIGURE: 1 / 2
GABRB3 Antibody (MA5-27698) in IHC (P)
Immunohistochemistry analysis of GABRB3 in rat brain. Samples were incubated with GABRB3 monoclonal antibody (Product # MA5-27698) using a dilution of 1:1000 (1 hour at RT) and followed by Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) and Mayer Hematoxylin (purple/blue) at a dilution of 250-500 µl.
Product Details
MA5-27698
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N87/25
Immunogen
Fusion protein amino acids 370-433 of mouse GABA-A-R-Beta 3
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
1 µg/mL of MA5-27698 was sufficient for detection of Beta 3 GABA receptor in 10 µg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 55kDa. No cross-reactivity against GABA-A-R-Beta 2 or -Beta1.
Target Information
Gamma-amino butyric acid (GAMA) is a strong inhibitor of neuron transmission and is found throughout the central nervous system. GABA is formed by the decarboxylation of glutamate, resulting in the formation of one of two distinct types; GABA-A or GABA-B.The binding of GABA to GABA-A receptors results in the increase transportation of chlorine ions into the neuron. This influx results in signal transmission repression. Studies have shown that if cell to cell signaling goes unchecked due to a lack of GABA, a system overload can resulting in blackouts, rapid body contractions, seizures and epilepsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cleft palate 1; GABA(A) receptor subunit beta-3; GABA-alpha receptor beta-2 subunit; GABAA receptor beta-3 subunit; GABAAR subunit beta-3; GABR B3; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) A receptor, beta 3; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3; gamma-aminobutyric acid A receptor beta 3; Gamma-aminobutyric acid receptor beta 3; Gamma-aminobutyric acid receptor subunit beta-3; gamma-aminobutyric acid receptor, subunit beta 3; MGC9051; testis gamma-aminobutyric acid receptor subunit beta 3
Gene Aliases: A230092K12Rik; AW049585; beta3; Cp1; ECA5; Gabrb-3; GABRB3
UniProt ID: (Human) P28472, (Mouse) P63080, (Rat) P63079
Entrez Gene ID: (Human) 2562, (Mouse) 14402, (Rat) 24922
transport
signal transduction
sensory perception of sound
ion transmembrane transport
negative regulation of neuron apoptotic process
palate development
inhibitory postsynaptic potential
inner ear receptor cell development
innervation
cellular response to histamine
cochlea development
chloride transmembrane transport
ion transport
chloride transport
gamma-aminobutyric acid signaling pathway
regulation of neuron apoptotic process
neuron development
synaptic transmission, GABAergic
negative regulation of neuron death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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