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Invitrogen
Caveolin 2 Recombinant Rabbit Monoclonal Antibody (8I4U7)
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FIGURE: 1 / 4
Caveolin 2 Antibody (MA5-35600) in IHC (P)
Immunohistochemistry analysis of Caveolin 2 in paraffin-embedded human esophageal cancer. Samples were incubated with Caveolin 2 Monoclonal antibody (Product # MA5-35600) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
MA5-35600
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
8I4U7
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Caveolin-2 (P51636)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MGLETEKADV QLFMDDDSYS HHSGLEYADP EKFADSDQDR DPHRLNSHLK LGFEDVIAEP VTTHSFDKVW ICSHALFEIS KYVMYKFLTV FLAIPLAFIA
Target Information
Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are known to encode 21-24 kDa integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: caveolae; caveolae protein, 20-kD; caveolin 2 isoform a and b; Caveolin-2; MGC12294; Phospho-CAV2
Gene Aliases: AI447843; CAV; CAV2
UniProt ID: (Human) P51636, (Mouse) Q9WVC3
Entrez Gene ID: (Human) 858, (Mouse) 12390
protein binding
protein kinase binding
protein binding, bridging
protein complex scaffold
protein homodimerization activity
protein heterodimerization activity
scaffold protein binding
SNARE binding
syntaxin binding
mitogen-activated protein kinase kinase kinase binding
D1 dopamine receptor binding
phosphoprotein binding
scaffold/adaptor protein
negative regulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
vesicle fusion
mitochondrion organization
endoplasmic reticulum organization
regulation of mitotic nuclear division
insulin receptor signaling pathway
vesicle organization
receptor-mediated endocytosis of virus by host cell
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of MAPK cascade
positive regulation of GTPase activity
positive regulation by host of viral release from host cell
positive regulation by host of viral process
vesicle docking
skeletal muscle fiber development
protein oligomerization
positive regulation of dopamine receptor signaling pathway
caveola assembly
endocytosis
chemical synaptic transmission
negative regulation of cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of protein localization to nucleus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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