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Invitrogen
Cathepsin H/K/L/V Recombinant Rabbit Monoclonal Antibody (2Q10F10)
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FIGURE: 1 / 3
Cathepsin H/K/L/V Antibody (MA5-35614) in IHC (P)
Immunohistochemistry analysis of Cathepsin H/K/L/V in paraffin-embedded human liver cancer. Samples were incubated with Cathepsin H/K/L/V Monoclonal antibody (Product # MA5-35614) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
MA5-35614
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
2Q10F10
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Cathepsin L/V/K/H (P07711)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: AVWEKNMKMI ELHNQEYREG KHSFTMAMNA FGDMTSEEFR QVMNGFQNRK PRKGKVFQEP LFYEAPRSVD WREKGYVTPV KNQGQCGSCW AFSATGALEG Q
Target Information
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aleurain; Cat H; Cat K; Cat L; Cathepsin B3; Cathepsin BA; Cathepsin K; Cathepsin L1; Cathepsin L2; cathepsin L2, preproprotein; Cathepsin O; cathepsin O1; Cathepsin O2; Cathepsin U; Cathepsin V; Cathepsin X; CP-2; Cyclic protein 2; furless; Major excreted protein; MEP; minisatellite 10q detected by probe MMS10; N-benzoylarginine-beta-naphthylamide hydrolase; nackt; p39 cysteine proteinase; Pro-cathepsin H; Procathepsin L
Gene Aliases: 1190035F06Rik; ACC-4; ACC-5; ACC4; ACC5; AI323530; AL022844; CATHL; catK; CATL; CATL2; CPSB; CTS02; CTSH; CTSK; CTSL; CTSL1; CTSL2; CTSO; CTSO1; CTSO2; CTSU; CTSV; fs; MEP; MMS10-Q; Ms10q; nkt; PKND; PYCD; UNQ268/PRO305
UniProt ID: (Human) P09668, (Human) P43235, (Human) P07711, (Human) O60911, (Rat) P00786, (Mouse) P49935, (Rat) O35186, (Mouse) P55097, (Mouse) P06797, (Rat) P07154
Entrez Gene ID: (Human) 1512, (Human) 1513, (Human) 1514, (Human) 1515, (Rat) 25425, (Mouse) 13036, (Rat) 29175, (Mouse) 13038, (Mouse) 13039, (Rat) 25697
endopeptidase activity
aminopeptidase activity
cysteine-type endopeptidase activity
serine-type endopeptidase activity
protein binding
peptidase activity
cysteine-type peptidase activity
cysteine-type endopeptidase activator activity involved in apoptotic process
HLA-A specific activating MHC class I receptor activity
thyroid hormone binding
fibronectin binding
collagen binding
proteoglycan binding
histone binding
serpin family protein binding
cysteine-type carboxypeptidase activity
kininogen binding
protein complex binding
peptide binding
peptidase activator activity involved in apoptotic process
protein self-association
hydrolase activity
cysteine protease
metanephros development
T cell mediated cytotoxicity
adaptive immune response
immune response-regulating signaling pathway
proteolysis
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of epithelial cell migration
neuropeptide catabolic process
bradykinin catabolic process
positive regulation of peptidase activity
antigen processing and presentation
positive regulation of cell migration
zymogen activation
protein destabilization
response to retinoic acid
membrane protein proteolysis
negative regulation of apoptotic process
surfactant homeostasis
cellular protein metabolic process
positive regulation of angiogenesis
proteolysis involved in cellular protein catabolic process
dichotomous subdivision of terminal units involved in lung branching
ERK1 and ERK2 cascade
cellular response to thyroid hormone stimulus
positive regulation of apoptotic signaling pathway
intramembranous ossification
toll-like receptor signaling pathway
extracellular matrix disassembly
collagen catabolic process
bone resorption
regulation of mitophagy
positive regulation of protein targeting to mitochondrion
antigen processing and presentation of exogenous peptide antigen via MHC class II
macrophage apoptotic process
spermatogenesis
cellular response to starvation
response to glucose
multicellular organism aging
negative regulation of keratinocyte proliferation
protein autoprocessing
nerve development
hair follicle morphogenesis
response to gonadotropin
decidualization
autophagic cell death
response to glucocorticoid
Sertoli cell differentiation
regulation of actin cytoskeleton reorganization
cell communication
protein processing
catagen
epithelial tube branching involved in lung morphogenesis
male gonad development
response to organic cyclic compound
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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