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Invitrogen
GATA6 Recombinant Rabbit Monoclonal Antibody (23GB5525)
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FIGURE: 1 / 3
GATA6 Antibody (MA5-52874) in ICC/IF
Immunocytochemistry analysis of GATA6 in HT-1080 cells. Sample was incubated with GATA6 monoclonal (Product # MA5-52874) antibody at a dilution of 1:1,000, followed by DAPI and Alexa Fluor 647. Protein abundance based on laser intensity and smart gain: Medium. Scale bar: 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-52874
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB5525
Immunogen
A synthesized peptide derived from human Gata 6 (550-595AA).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.15 mg/mL
Amount
115 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The GATA6 gene encodes a member of the GATA family of zinc-finger transcription factors, which are critical in regulating gene expression during development. GATA6 plays a crucial role in the differentiation and development of multiple tissues, including the heart and gastrointestinal tract, by interacting with other transcriptional regulators through its zinc-finger domains. This gene influences signaling pathways that drive epithelial-to-mesenchymal transitions (EMTs) and immune surveillance, which are essential processes in maintaining tissue homeostasis and countering tumor progression. In the respiratory tract, GATA6 is essential for the differentiation of lung epithelial cells, impacting the expression of WNT7B and surfactant proteins, vital for proper lung function. Furthermore, studies suggest that GATA6 contributes to an immune-enriched phenotype linked to favorable prognostic outcomes in certain cancers, indicating its potential role in mitigating metastatic propensity by enhancing immune response and surveillance against tumorous cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ASD9; AVSD5; DNA-binding protein GATA-GT2; GATA-binding factor 6; GATA-binding protein 6; Transcription factor GATA-6
Gene Aliases: AA410133; GATA-6; GATA6
UniProt ID: (Rat) P46153, (Mouse) Q61169
Entrez Gene ID: (Rat) 29300, (Mouse) 14465
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
RNA polymerase II repressing transcription factor binding
enhancer sequence-specific DNA binding
DNA binding
chromatin binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor binding
zinc ion binding
protein kinase binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein binding
metal ion binding
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
liver development
outflow tract septum morphogenesis
type B pancreatic cell differentiation
pancreatic A cell differentiation
transcription, DNA-templated
transcription from RNA polymerase II promoter
phospholipid metabolic process
endodermal cell fate determination
male gonad development
response to toxic substance
regulation of gene expression
cardiac muscle hypertrophy in response to stress
positive regulation of BMP signaling pathway
epithelial cell differentiation
pancreas development
negative regulation of transforming growth factor beta1 production
negative regulation of transforming growth factor beta2 production
tube morphogenesis
endodermal cell differentiation
odontogenesis of dentin-containing tooth
response to drug
positive regulation of apoptotic process
negative regulation of apoptotic process
response to estrogen
positive regulation of angiogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
organ formation
cardiac muscle tissue development
smooth muscle cell differentiation
response to cAMP
positive regulation of cardioblast differentiation
cardiac muscle cell differentiation
positive regulation of cardiac muscle cell proliferation
lung saccule development
Clara cell differentiation
Type II pneumocyte differentiation
intestinal epithelial cell differentiation
cardiac vascular smooth muscle cell differentiation
response to growth factor
positive regulation of cell cycle arrest
cellular response to gonadotropin stimulus
cellular response to hypoxia
cellular response to BMP stimulus
regulation of transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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