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Invitrogen
PKC iota Polyclonal Antibody
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Product Details
PA5150155
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Kinase C Iota (PKCi) (Ile375-Val596)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Protein Kinase C iota (PKC iota), also known as PRKCI, is an atypical isoform of Protein Kinase C that plays significant roles in cellular signaling. The PKC iota gene is positioned on the human chromosome 3, specifically at 3q26. Its structure is characterized by an absence of the calcium and diacylglycerol regulatory domains that are typically found in conventional PKC isoforms, allowing it to function independently of these signals. PKC iota has been identified as a bona fide oncogene, implicated in various cancers, including lung and ovarian cancers. It is involved in biological processes such as cell differentiation, proliferation, and survival by influencing pathways like NF-?B activation. PKC iota interacts with TRAF6 and IRAK to activate I?B kinase-β, prompting NF-?B to translocate to the nucleus and promote gene expression related to cell survival and growth. Molecular cloning studies have detailed its structure, which is pre-organized before substrate binding, differing considerably from other kinase family members like PKA. PKC iota's critical role in cancer progression and its potential as a prognostic marker make it a key target for therapeutic research, particularly in oncogenic pathways linked to K-Ras mutations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aPKC-lambda/iota; Atypical protein kinase C-lambda/iota; nPKC-iota; PKC-iota; PRKC-lambda/iota; Protein kinase C iota type; protein kinase C, iota; protein kinase C, lambda
Gene Aliases: 2310021H13Rik; AI427505; aPKClambda; DXS1179E; mKIAA4165; nPKC-iota; PKCI; Pkcl; PKClambda; PRKCI; Prkcl
UniProt ID: (Human) P41743, (Mouse) Q62074, (Rat) F1M7Y5
Entrez Gene ID: (Human) 5584, (Mouse) 18759, (Rat) 84006
protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
protein binding
ATP binding
phospholipid binding
protein domain specific binding
metal ion binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
molecular_function
non-receptor serine/threonine protein kinase
protein phosphorylation
protein targeting to membrane
cytoskeleton organization
actin filament organization
positive regulation of neuron projection development
vesicle-mediated transport
cell migration
peptidyl-serine phosphorylation
cellular response to insulin stimulus
negative regulation of glial cell apoptotic process
establishment of apical/basal cell polarity
intracellular signal transduction
eye photoreceptor cell development
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
establishment or maintenance of epithelial cell apical/basal polarity
cell-cell junction organization
positive regulation of glucose import
secretion
Golgi vesicle budding
positive regulation of NF-kappaB transcription factor activity
positive regulation of glial cell proliferation
membrane organization
response to interleukin-1
bicellular tight junction assembly
positive regulation of establishment of protein localization to plasma membrane
positive regulation of endothelial cell apoptotic process
multicellular organism development
phosphorylation
cellular protein localization
response to peptide hormone
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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