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Invitrogen
Phospho-Girdin (Ser1417) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-Girdin (Ser1417) Antibody (PA5-37796) in IHC (P)
Immunohistochemical analysis of Phospho-Girdin (Ser1417) in paraffin-embedded Human breast carcinoma tissue using Phospho-Girdin (Ser1417) Polyclonal Antibody (Product # PA5-37796) (left) or the same antibody preincubated with blocking peptide (right).
Product Details
PA5-37796
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide sequence around phosphorylation site of Serine 417(L-E-M(p)-A-Q) derived from Human Girdin.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control for IHC is human breast carcinoma.
Target Information
Girdin is a Galpha-interacting protein that can enhance the activation of the protein kinase Akt, remodel the actin cytoskeleton, and is thought to be involved in the regulation of cell migration and cancer metastasis. It has recently been shown that Girdin interacts with Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders. DISC1 is thought to be involved in the migration, positioning and differentiation of dentate granule cells (DGCs) during development; depletion of Girdin or blocking the Girdin-DISC1 interaction results in defects in axonal sprouting in the CA3 region of the hippocampus and overextended migration of mispositioning of DGCs, suggesting the Girdin plays a role in postnatal neurogenesis in the dentate gyrus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Akt phosphorylation enhancer; AKT-phosphorylation enhancer; APE; Coiled-coil domain-containing protein 88A; G alpha-interacting vesicle-associated protein; Girders of actin filament; girders of actin filaments; Girdin; GIV; HkRP1; Hook-related protein 1
Gene Aliases: A430106J12Rik; AI848406; APE; C130096N06Rik; C330012F17Rik; CCDC88A; D130005J21Rik; GIRDIN; GIV; GRDN; HkRP1; KIAA1212
UniProt ID: (Human) Q3V6T2, (Mouse) Q5SNZ0
Entrez Gene ID: (Human) 55704, (Mouse) 108686
regulation of protein phosphorylation
DNA replication
regulation of DNA replication
regulation of neuron projection development
cell migration
lamellipodium assembly
TOR signaling
activation of protein kinase B activity
regulation of actin cytoskeleton organization
regulation of cell proliferation
membrane organization
nervous system development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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