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Invitrogen
Human Glucocorticoid Receptor, Ligand Binding Domain, GST Tag Recombinant Protein
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产品信息
A15668
产品规格
种属
Human
Expression System
Baculovirus
氨基酸序列
521-777
标签
GST-tag
分类
Recombinant
类型
Protein
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
See Label
Amount
4.5 mg
纯化类型
purified
保存液
proprietary buffer
内含物
no preservative
保存条件
-80°C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
Glucocorticoid receptor ligand binding domain (GR-LBD) is a 57.85 kDa recombinant human protein (amino acids 521-777) expressed as a glutathione-S-transferast (GST) fusion protein in baculovirus-infected insect cells. GR-LBD is expressed and purified in the absence of exogenous ligands, making it ideal for ligand binding and coregulator displacement studies.
GR-LBD human recombinant protein is:
• Flexible—use in your in-house assay or as part of our LanthaScreen™ Coactivator or Competitive Binding assays for a complete assay solution
• Ready to use—active and tagged (with GST)
• Convenient—available in bulk sizes
Contact us for bulk quantities or for assistance with other nuclear receptor assay needs, from assay development to library screening and beyond.
Protein Form: Ligand Binding Domain, Recombinant
靶标信息
Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. Glucocorticoid Receptor can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Glucocorticoid Receptor is expressed in the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. Mutations in the Glucocorticoid Receptor gene are a cause of glucocorticoid resistance, or cortisol, resistance. Studies have shown that glucocorticoid receptor (GR) must be associated with a complex of chaperone proteins for ligand activation. GR binds to known steroids such as dexamethasone with nanomolar affinity
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GR; gr alpha; GR Kit; hGR DL-1; hGR NS-1; nuclear receptor subfamily 3 group C member 1 variant hGR-B(54); nuclear receptor subfamily 3 group C member 1 variant hGR-B(77); nuclear receptor subfamily 3 group C member 1 variant hGR-B(93); nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); OTTHUMP00000222854; OTTHUMP00000222858; putative upstream ORF.; Unknown; unnamed protein product
基因别名: GCCR; GCR; GCRST; GR; GRL
UniProt ID: (Human) P04150
Entrez Gene ID: (Human) 2908
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