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Invitrogen
Human LYN A, GST Tag Recombinant Protein
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产品信息
PV6449
产品规格
种属
Human
Expression System
Baculovirus
氨基酸序列
Full length
标签
GST-tag
分子量
81 kDa
分类
Recombinant
类型
Protein
偶联物
形式
Liquid
浓度
See Label
纯化类型
purified
保存液
50nM tris HCl, pH 7.5, with 25% glycerol, 0.25mM DTT, 0.1mM EGTA, 150mM NaCl, 0.1mM PMSF, 0.1mM EDTA
内含物
no preservative
保存条件
-80°C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
• Increase disease relevance by interrogating a purified and active full-length LYN A reagent
• Uncover novel compounds or hits specific to the full length form
• Advance your research using the full-length protein and validated assays
Assay Platforms:
LanthaScreen™ TR-FRET Kinase Activity Assay
LanthaScreen™ Eu Kinase Binding Assay
Z’-LYTE™ Kinase Activity Assay
Protein Form: Full Length
The gene accession number for LYN A is NP_002341.1.
靶标信息
LYN (v-yes-1 Yamaguchi sarcoma viral related oncogene homolog) is a SRC family kinase expressed predominantly in hematopoietic, neural, liver, and adipose tissue. It is a protein-coding gene and is associated with diseases such as alexia and chorea-acanthocytosis. Activation of LYN has been shown to lead to imatinib resistance in CML patients. LYN B and the slightly shorter LYN A are the two isoforms of LYN. An important paralog of Lyn Isoform A is FRK. The full length LYN A protein enables researchers to study important mechanisms underlying disease. Diseases associated with LYN include Sarcoma and Myeloid Leukemia. Among its related pathways are Signaling by Erythropoietin and Regulation of actin dynamics for phagocytic cup formation. Gene Ontology (GO) annotations related to Lyn Isoform A include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of Lyn Isoform A is HCK.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Lck/Yes-related novel protein tyrosine kinase; LYN; p53Lyn; p56Lyn; Tyrosine-protein kinase Lyn; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog
基因别名: JTK8; LYN; p53Lyn; p56Lyn
UniProt ID: (Human) P07948
Entrez Gene ID: (Human) 4067
