Invitrogen

Mouse NOXA Synthetic Peptide

Name: Mouse NOXA Synthetic Peptide
Brand: Invitrogen
SKU: PEP-0305

说明书

技术支持

说明书

技术支持

说明书

技术支持

产品信息

PEP-0305

应用

建议稀释比

已发表文章

中和实验 (Neu)

Assay-dependent

产品规格

种属反应

Mouse

分类

Synthetic

类型

Peptide

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

purified

保存液

PBS, pH 7.2, with 0.1% BSA

内含物

0.02% sodium azide

保存条件

-20°C

产品详细信息

This peptide corresponds to 17 amino acids near the amino terminus of mouse Noxa.

PEP-0305 can be used as a blocking peptide with polyclonal antibody PA5-19977.

靶标信息

Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development.

仅用于科研。不用于诊断过程。未经明确授权不得转售。