CD22 Proteins

CD22 Human recombinant proteins are validated for use in the following applications: Neutralization, Binding assay, ELISA standard, Bioactivity and Western blot control. These proteins are expressed in CHO cells, E. coli and HEK293 cells. Available Product Grades: Research Use Only. Gibco and... CD22 Human recombinant proteins are validated for use in the following applications: Neutralization, Binding assay, ELISA standard, Bioactivity and Western blot control. These proteins are expressed in CHO cells, E. coli and HEK293 cells. Available Product Grades: Research Use Only. Gibco and Invitrogen proteins are some of the most frequently... CD22 Human recombinant proteins are validated for use in the following applications: Neutralization, Binding assay, ELISA standard, Bioactivity and Western blot control. These proteins are expressed in CHO cells, E. coli and HEK293 cells. Available Product Grades: Research Use Only. Gibco and Invitrogen proteins are some of the most frequently published proteins. CD22 Protein have been referenced in 1 publications which can be found in our reference library. Our Gibco brand includes SKUs from PeproTech™, acquired by Thermo Fisher Scientific. Browse all 6 proteins, including biologically active options. Not finding the exact protein, grade or size needed?... CD22 Human recombinant proteins are validated for use in the following applications: Neutralization, Binding assay, ELISA standard, Bioactivity and Western blot control. These proteins are expressed in CHO cells, E. coli and HEK293 cells. Available Product Grades: Research Use Only. Gibco and Invitrogen proteins are some of the most frequently published proteins. CD22 Protein have been referenced in 1 publications which can be found in our reference library. Our Gibco brand includes SKUs from PeproTech™, acquired by Thermo Fisher Scientific. Browse all 6 proteins, including biologically active options. Not finding the exact protein, grade or size needed? Contact us to discuss your specific application and product needs.

Protein Information

CD22, also known as BL-CAM, is a type I transmembrane glycoprotein composed of two polypeptide chains, CD22alpha and CD22beta, with molecular weights of 130 and 140 kDa, respectively. These chains are produced by alternative splicing of the CD22 gene. CD22 is prominently expressed on mature B cells and B cell lymphomas, including hairy cell leukemia, diffuse large B-cell lymphoma, and nodular lymphocyte predominance Hodgkin’s lymphoma, but is negative in classical Hodgkin’s lymphoma. The extracellular portion of CD22 contains seven Ig-like domains that preferentially bind alpha2,6-linked sialic acid moieties found on epithelial, endothelial, B, and T cells. This binding can be masked by cis interactions with sialic acids on the same cell surface. CD22 expression is limited to late stages of B-cell differentiation, making it useful for phenotyping mature leukemias. Intracellularly, CD22 features six tyrosine residues within immunotyrosine-based inhibitory motifs (ITIM) and activation-like motifs. These residues are phosphorylated upon B-cell receptor engagement, allowing CD22 to regulate B-cell receptor signaling. CD22 participates in positive regulation through interactions with Src family tyrosine kinases and acts as an inhibitory receptor by recruiting cytoplasmic phosphatases via SH2 domains, which block signal transduction through dephosphorylation of signaling molecules. CD22's role in both positive and negative regulation of B-cell signaling, along with its specific expression pattern, makes it a valuable marker for antibody customers interested in B-cell-related research and diagnostics.

Synonyms

A530093D23; B-cell receptor CD22; BL-CAM; B-lymphocyte cell adhesion molecule; B-lymphocyte cell adhesion molecule (BL-CAM); Cd22; CD22 antigen; CD22 molecule; FLJ22814; Lectin 2; Leu-14; Lyb8; Lyb-8; MGC130020; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2; Sialic acid-binding Ig-like lectin 2 (Siglec-2); Siglec2; Siglec-2; T-cell surface antigen Leu-14

CD22 Proteins

Protein Information

Synonyms

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