M-CSF Proteins

M-CSF recombinant proteins are available for Human, Mouse and Rat. These Protein have been validated for use in the following applications: Bioactivity, Western blot control and ELISA standard. These proteins are expressed in E. coli and HEK293 cells. Available Product Grades: Animal-Free and... M-CSF recombinant proteins are available for Human, Mouse and Rat. These Protein have been validated for use in the following applications: Bioactivity, Western blot control and ELISA standard. These proteins are expressed in E. coli and HEK293 cells. Available Product Grades: Animal-Free and Research Use Only. Gibco and Invitrogen proteins are... M-CSF recombinant proteins are available for Human, Mouse and Rat. These Protein have been validated for use in the following applications: Bioactivity, Western blot control and ELISA standard. These proteins are expressed in E. coli and HEK293 cells. Available Product Grades: Animal-Free and Research Use Only. Gibco and Invitrogen proteins are some of the most frequently published proteins. M-CSF Protein have been referenced in 1469 publications which can be found in our reference library. Our Gibco brand includes SKUs from PeproTech™, acquired by Thermo Fisher Scientific. Browse all 9 proteins, including biologically active options. Not finding the exact protein, grade or size needed?... M-CSF recombinant proteins are available for Human, Mouse and Rat. These Protein have been validated for use in the following applications: Bioactivity, Western blot control and ELISA standard. These proteins are expressed in E. coli and HEK293 cells. Available Product Grades: Animal-Free and Research Use Only. Gibco and Invitrogen proteins are some of the most frequently published proteins. M-CSF Protein have been referenced in 1469 publications which can be found in our reference library. Our Gibco brand includes SKUs from PeproTech™, acquired by Thermo Fisher Scientific. Browse all 9 proteins, including biologically active options. Not finding the exact protein, grade or size needed? Contact us to discuss your specific application and product needs.

Protein Information

M-CSF (Macrophage colony-stimulating factor, CSF-1) is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells. M-CSF also induces VEGF (vascular endothelial growth factor) secretion by macrophages, thereby mediating mobilization of endothelial progenitor cells and neovascularization. M-CSF is present as several bioactive isoforms that differ in potency and stability. The full-length protein is synthesized as a membrane-spanning protein that can be expressed on the cell surface or further cleaved and modified in the secretory vesicle. Further, M-CSF is a disulfide-bonded homodimer which is processed into one of two isoforms, a glycoprotein or a proteoglycan that has been modified by the addition of chondroitin sulfate to each subunit. Binding of M-CSF to its receptor, c-Fms (CSF-1R or CD115) induces dimerization of the receptor followed by internalization and degradation of the complex. Functionally, M-CSF is known to stimulate differentiation of hematopoietic stem cells to monocyte-macrophage cell populations in culture. M-CSF acts through the CSF receptor 1. Although human M-CSF shows activity on mouse cells, mouse CSF shows no activity on human cells.

同义词

C87615; colony stimulating factor 1; colony stimulating factor 1 (macrophage); colony-stimulating factor-1 splice variant; CSF1; CSF-1; Csfm; H-MCSF; lanimostim; macrophage colony stimulating factor 1; macrophage colony stimulating factor alpha; macrophage colony stimulating factor beta; macrophage colony-stimulating factor; macrophage colony-stimulating factor 1; macrophage colony-stimulating factor beta; macrophage-colony stimulating factor alpha; MCSF; MCSF alpha; MCSFBETA; MGC31930; M-MCSF; op; osteopetrosis; Processed macrophage colony-stimulating factor 1

M-CSF Proteins

Protein Information

同义词

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