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This gene encodes for a protein that in yeast forms part of a trimeric vacuolar-protein-sorting complex that is required for retrograde transport of proteins from prevacuoles to the late Golgi compartment. As in yeast, mammalian Vps54 proteins contain a coiled-coil region and dileucine motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.
Hcc8; Hepatocellular carcinoma protein 8; hVps54L; mSLP8; PPP1R164; protein phosphatase 1, regulatory subunit 164; SLP-8p; Tumor antigen HOM-HCC-8; tumor antigen SLP-8p; Tumor antigen SLP-8p homolog; vacuolar protein sorting 54 (yeast); vacuolar protein sorting 54 homolog; vacuolar protein sorting 54 homolog (S. cerevisiae); vacuolar protein sorting-associated protein 54; VPS54; VPS54 GARP complex subunit; VPS54, GARP complex subunit; Vps54l; vps54-like protein; Vsp54; wr
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